Understanding how Ewing sarcoma affects gene transcription
Phase separation control of transcription in Ewing sarcoma
This study is looking at how a specific protein linked to Ewing sarcoma affects how genes work in cells, with the hope of finding new ways to treat this type of bone cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10983780 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the EWS-FLI1 fusion protein, commonly found in Ewing sarcoma, alters gene transcription. It focuses on how this protein interacts with other proteins to form granules that disrupt normal cellular processes, potentially leading to tumor development. By isolating these granules and studying their composition and function, the research aims to provide insights into the transcriptional regulation in Ewing sarcoma. This could help identify new therapeutic targets for this aggressive bone cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents diagnosed with Ewing sarcoma or those at risk due to genetic factors.
Not a fit: Patients with Ewing sarcoma who do not have the EWS-FLI1 fusion protein may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for Ewing sarcoma, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promise in understanding the role of protein interactions in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Schwartz, Jacob C. — University of Arizona
- Study coordinator: Schwartz, Jacob C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.