Identifying a specific protein linked to Ewing sarcoma in children and young adults
Discovery and characterization of exceptionally specific surface oncoprotein LIPI in Ewing Sarcoma
This study is looking at a protein called LIPI to see how it affects Ewing sarcoma, a cancer that mostly impacts kids and young adults, with the hope of finding new ways to use the immune system to treat this tough disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10883632 on NIH RePORTER |
What this research studies
This research focuses on Ewing sarcoma, a type of cancer that primarily affects children and young adults. The team is investigating a specific protein called LIPI, which is believed to play a crucial role in the cancer's development and progression. By analyzing gene expression data from cancerous and normal tissues, the researchers aim to understand how LIPI functions and its potential as a target for new immunotherapies. This could lead to innovative treatments that harness the immune system to fight this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults diagnosed with Ewing sarcoma, particularly those with metastatic disease.
Not a fit: Patients with Ewing sarcoma who are not eligible for immunotherapy or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies for children and young adults with Ewing sarcoma, improving their chances of recovery.
How similar studies have performed: While the specific focus on LIPI is novel, similar immunotherapy approaches have shown promise in treating other cancers, indicating potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Asangani, Irfan Ahmed — University of Pennsylvania
- Study coordinator: Asangani, Irfan Ahmed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.