Condition

Germ Cell Tumor clinical trials and research

• 19Clinical trials
• 2NIH research projects
• 25Countries

Newest Germ Cell Tumor clinical trials

All recruiting trials (19)

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• Teniposide plus cisplatin for newly diagnosed central malignant germ cell tumors

  This trial tests whether giving teniposide together with cisplatin helps people newly diagnosed with central malignant germ cell tumors.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07188441

• ZW251 for advanced liver, lung, and germ cell cancers

  This will test whether ZW251, an antibody-drug conjugate that targets GPC3, is safe and can shrink tumors in adults with advanced hepatocellular carcinoma, squamous cell non-small cell lung cancer, or germ cell tumors.

  Recruiting at 25 sites Phase 1 Zymeworks BC Inc. · San Francisco, California and 24 other locations · NCT07164313

• Maintenance zanzalintinib with oral etoposide after high-dose chemotherapy for germ cell tumor

  This treatment tests whether daily zanzalintinib together with cycles of oral etoposide can help people with relapsed or refractory germ cell tumors after high-dose chemotherapy and stem-cell transplant.

  Recruiting Phase 1/2 Indiana University · Indianapolis, Indiana · NCT06937866

• Low-dose aspirin to prevent venous blood clots during chemotherapy for advanced germ cell (testicular) cancer

  This trial will see if taking one daily low-dose aspirin (81 mg) during cisplatin chemotherapy prevents venous blood clots over six months in adults up to age 70 with high-risk advanced germ cell or testicular cancer.

  Recruiting at 3 sites Phase 2 Wake Forest University Health Sciences · Charlotte, North Carolina and 2 other locations · NCT06866964

• Creating a database for mediastinal tumors at Peking Union Medical College Hospital

  This study is creating a database to help doctors better understand and treat different types of mediastinal tumors by collecting information on their characteristics and imaging results.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06421805

• High-dose chemotherapy for relapsed germ cell tumors

  This study is testing if high-dose chemotherapy can help people with relapsed germ cell tumors who didn't respond to their first treatment feel better and live longer.

  Recruiting Phase 2 N.N. Petrov National Medical Research Center of Oncology · Saint Petersburg, Russian Federation · NCT06418789

• Safety and tolerability of XmAb541 in patients with advanced solid tumors

  This study is testing a new drug called XmAb541 to see if it's safe and how well it works for people with advanced solid tumors like ovarian and endometrial cancer.

  Recruiting at 27 sites Phase 1 Xencor, Inc. · Duarte, California and 26 other locations · NCT06276491

• Robot-assisted biopsy for testicular cancer

  This study is testing a new robot-assisted method for taking biopsies in men with testicular cancer to see if it can more accurately find hidden cancer and reduce unnecessary treatments.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT06133543

• Preventing blood clots in patients with advanced germ cell tumors undergoing chemotherapy

  This study is testing whether a blood clot prevention treatment can help people with advanced germ cell tumors who are getting chemotherapy avoid serious blood clots.

  Recruiting at 18 sites Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Angers and 25 other locations · NCT05874063

• Investigating genetic and molecular profiles of pediatric brain tumors in China

  This study is trying to understand the genetic makeup of brain tumors in children to see how it affects their treatment and recovery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05672043

• Understanding the long-term effects of pediatric germ cell tumors

  This study is trying to understand the long-term effects of treatment on kids and teens who survived germ cell tumors to see how their health might change over time.

  Recruiting Children's Oncology Group · Minneapolis, Minnesota · NCT05564026

• Observational assessment of treatment outcomes for patients with primary brain tumors

  This study looks at how well treatments work for people with rare primary brain tumors using new classification guidelines to see if they help doctors group patients better.

  Recruiting at 42 sites European Organisation for Research and Treatment of Cancer - EORTC · Innsbruck and 41 other locations · NCT05259605

• Oral etoposide versus observation after high-dose chemotherapy for relapsed germ cell tumors

  This study is testing if taking daily oral etoposide after high-dose chemotherapy can help people with relapsed germ cell tumors do better than just watching and waiting.

  Recruiting Phase 2 Indiana University · Indianapolis, Indiana · NCT04804007

• Combining vorinostat with chemotherapy for relapsed solid tumors and CNS cancers

  This study is testing if adding a drug called vorinostat to chemotherapy can help people with relapsed solid tumors and brain cancers feel better and improve their treatment outcomes.

  Recruiting Phase 1 New York Medical College · Valhalla, New York · NCT04308330

• Locoregional immunotherapy using CAR T cells for pediatric brain tumors

  This study is testing a new treatment using specially modified immune cells to see if it can help children and young adults with certain types of brain tumors feel better.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT04185038

• Monitoring and treating germ cell tumors in children and adults

  This study is testing whether a combination of careful monitoring and chemotherapy can help children and adults with low-risk germ cell tumors stay healthy after surgery, while also comparing two different chemotherapy drugs and looking at their effects on hearing.

  Recruiting at 438 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 628 other locations · NCT03067181

• Accelerated versus standard BEP chemotherapy for intermediate and poor‑risk metastatic germ cell tumours

  This trial will test whether giving BEP chemotherapy every 2 weeks instead of every 3 weeks helps males (typically aged 11–50) with intermediate- or poor‑risk metastatic germ cell tumours do better.

  Recruiting at 53 sites Phase 3 University of Sydney · Downey, California and 55 other locations · NCT02582697

• Registry for Germ Cell and Testicular Tumors

  This study is trying to gather information from people with germ cell and testicular tumors, their families, and healthy individuals to better understand how these tumors develop and how to treat them.

  Recruiting at 6 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT02099734

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How mistakes in egg cell division can cause infertility and germ cell tumors

  Researchers are studying how errors in the last steps of egg cell division can lead to eggs that can't be fertilized, miscarriages, or germ cell tumors.

  NIH research Dartmouth College · Hanover, United States · NIH-11112384

• Understanding the genetic causes of testicular germ cell tumors in children and adults

  This study is looking at how certain genes might play a role in testicular cancer, especially in young men and boys with unique genital conditions, to help find better ways to prevent and treat this type of cancer in the future.

  NIH research Children's Research Institute · Washington, United States · NIH-10926818

Related topics

Quick answers

How many Germ Cell Tumor clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (12 trials), United Kingdom (4 trials), China (3 trials), Spain (3 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 2: 4, Phase 3: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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