Targeting a specific enzyme to treat Ewing Sarcoma in children and adolescents
FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma
This study is looking at how a special enzyme helps Ewing Sarcoma cells survive, with the hope of finding new treatments for kids and teens with this type of cancer by using innovative techniques to block that enzyme.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11075134 on NIH RePORTER |
What this research studies
This research focuses on Ewing Sarcoma, a type of bone and soft tissue cancer that primarily affects children and adolescents. The team is investigating how Ewing Sarcoma cells rely on a specific enzyme called FEN1 for their survival. By using advanced techniques like CRISPR and small molecule inhibitors, the researchers aim to disrupt this dependency, potentially leading to more effective treatments. The project involves collaboration among experts in genetics, cancer biology, and pediatric oncology to explore new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with Ewing Sarcoma.
Not a fit: Patients with other types of cancers or those who are not diagnosed with Ewing Sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for Ewing Sarcoma, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Kolodner, Richard D — University of California, San Diego
- Study coordinator: Kolodner, Richard D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.