Targeting a protein to treat Ewing sarcoma in children
Investigating IGF2BP1 as a novel Therapeutic Target for Ewing Sarcoma
This study is looking at a protein called IGF2BP1 to see how it affects the growth of Ewing sarcoma, a type of bone cancer in kids, with the goal of finding better treatments for this tough disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11116836 on NIH RePORTER |
What this research studies
This research focuses on Ewing sarcoma, a serious bone cancer affecting children, and aims to identify a new therapeutic target called IGF2BP1. Using advanced techniques like CRISPR-Cas9, researchers will investigate how knocking out this protein affects cancer cell growth and survival. The study will also explore the underlying mechanisms of how IGF2BP1 contributes to the cancer's biology. By understanding these processes, the research hopes to develop more effective treatments for this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Ewing sarcoma, particularly those who have not responded well to existing treatments.
Not a fit: Patients with other types of cancers or those who are not diagnosed with Ewing sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies that improve outcomes for children with Ewing sarcoma.
How similar studies have performed: Other research has shown promise in targeting similar proteins in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Bond, Michael Joseph — Dana-Farber Cancer Inst
- Study coordinator: Bond, Michael Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.