Condition

Chordoma clinical trials and research

• 8Clinical trials
• 12Countries

Newest Chordoma clinical trials

All recruiting trials (8)

• Combination treatment of pembrolizumab and high-dose pemetrexed for chordoma

  This study is testing a new combination of two drugs, pembrolizumab and high-dose pemetrexed, to see if it can help people with progressive chordoma, a rare cancer.

  Recruiting Phase 2 Saint John's Cancer Institute · Santa Monica, California · NCT06794645

• Alpha/beta T‑Cell and B‑Cell Depletion plus Zoledronic Acid for Pediatric and Young Adult Solid Tumors

  This study will try removing alpha/beta T cells and B cells from donor stem cell grafts and giving zoledronic acid to see if it helps children and young adults (6 months to 25 years) with relapsed or high‑risk solid tumors tolerate allogeneic transplant and reduce relapse.

  Recruiting Phase 1/2 University of Florida · Gainesville, Florida · NCT06625190

• Comparing single vs double beam proton therapy for certain tumors

  This study is testing whether using one beam of proton therapy is just as effective and safer than using two beams for patients with certain types of tumors.

  Recruiting Centre Antoine Lacassagne · Nice · NCT06029218

• Proton therapy for chordomas and chondrosarcomas at the skull base

  This study is testing a new type of proton therapy to see if it can effectively treat chordomas and chondrosarcomas at the base of the skull while keeping side effects low and improving patients' quality of life.

  Recruiting Quironsalud · Madrid, Madrid · NCT05861245

• Comparing carbon ion therapy, surgery, and proton therapy for pelvic bone sarcomas

  This study is testing whether carbon ion therapy works better than surgery or proton therapy for treating pelvic bone sarcomas and how these treatments affect patients' quality of life.

  Recruiting at 3 sites Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT05033288

• Using imaging to improve proton therapy for chordomas and chondrosarcomas

  This study is testing if using advanced imaging techniques can help improve proton therapy for patients with aggressive bone tumors called chordomas and chondrosarcomas by better targeting the tumors and protecting healthy tissue.

  Recruiting at 2 sites Leiden University Medical Center · Delft, South Holland and 1 other locations · NCT04832620

• Observing the natural history of chordoma in children and adults

  This study is trying to learn more about how chordoma, a rare bone cancer, affects children and adults by tracking their health and treatment responses over time.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03910465

• Comparing surgery and radiation therapy for sacral chordoma treatment

  This study is testing whether surgery or radiation therapy works better for treating sacral chordoma in patients who have this localized tumor.

  Recruiting at 13 sites Italian Sarcoma Group · Graz and 27 other locations · NCT02986516

Related topics

Quick answers

How many Chordoma clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (4 trials), Netherlands (2 trials), Spain (2 trials), France (1 trial), Austria (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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