Investigating how proteoglycans affect signaling in Ewing sarcoma
Official title: Targeting proteoglycan-mediated signaling in Ewing sarcoma
Funded at Children's Hospital of Los Angeles · NIH-10873703 · Data updated 2026-11-12
This study is looking at how certain proteins affect the growth of Ewing sarcoma, a type of bone cancer, by using zebrafish to see how cancer cells behave in a living creature, which could help find new ways to treat this disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $117,915 |
| NIH project number | 5K99CA270282-02 |
| Project ID | NIH-10873703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Ewing sarcoma, particularly those with metastatic or relapsed disease.
✕Less likely to help
Patients with other types of cancers or those who do not have Ewing sarcoma may not benefit from this research.
What this research studies
This research focuses on Ewing sarcoma, a serious bone and soft-tissue cancer, by using a zebrafish model to understand how certain proteins called proteoglycans influence tumor growth and behavior. The study aims to explore the mechanisms of tumor initiation and progression by observing cancer cells in a living organism, which provides insights that are not possible in traditional mammalian models. Researchers will utilize advanced techniques such as single-cell transcriptomics and high-resolution imaging to analyze the interactions between cancer cells and their environment, potentially leading to new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the signaling pathways involved in Ewing sarcoma, improving outcomes for patients.
How similar studies have gone: Other research has shown promise in targeting proteoglycan signaling in various cancers, suggesting that this approach could be effective in Ewing sarcoma as well.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Vasileva, Elena — Children's Hospital of Los Angeles
- Study coordinator: Vasileva, Elena
Related research
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RAPID: A patient-centered, fast-tracked drug trial platform for young people with relapsed Ewing sarcoma and DSRCT
A patient-friendly, open-label phase 2 platform trial tests promising drug combinations for teens and young adults whose Ewing sarcoma or DSRCT has come back or not responded to treatment.
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TGFβ brakes immune evasion and metastasis in Ewing sarcoma during radiation
A physician-scientist will study whether blocking TGFβ during radiation can help CAR T cells fight Ewing sarcoma and improve patient outcomes.
-
Function and Targeting of ETV6 in Ewing Sarcoma
A scientist at Case Western Reserve University is studying a specific protein, ETV6, that helps a rare bone cancer called Ewing sarcoma, with the goal of finding targeted therapies that could spare healthy cells.
-
Targeting immune markers in Ewing Sarcoma to guide safer, more effective therapies
A funded project at Stanford aims to use immune markers on Ewing Sarcoma to develop targeted immunotherapies that work in children and adults with this cancer.
-
Ewing sarcoma: how DNA repair weaknesses affect risk and treatment
A clinician-researcher team at Dana-Farber is studying how DNA damage repair weaknesses help drive Ewing sarcoma in kids and teens, with the goal of better predicting risk and guiding therapy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.