Investigating how proteoglycans affect signaling in Ewing sarcoma
Targeting proteoglycan-mediated signaling in Ewing sarcoma
This study is looking at how certain proteins affect the growth of Ewing sarcoma, a type of bone cancer, by using zebrafish to see how cancer cells behave in a living creature, which could help find new ways to treat this disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10873703 on NIH RePORTER |
What this research studies
This research focuses on Ewing sarcoma, a serious bone and soft-tissue cancer, by using a zebrafish model to understand how certain proteins called proteoglycans influence tumor growth and behavior. The study aims to explore the mechanisms of tumor initiation and progression by observing cancer cells in a living organism, which provides insights that are not possible in traditional mammalian models. Researchers will utilize advanced techniques such as single-cell transcriptomics and high-resolution imaging to analyze the interactions between cancer cells and their environment, potentially leading to new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Ewing sarcoma, particularly those with metastatic or relapsed disease.
Not a fit: Patients with other types of cancers or those who do not have Ewing sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the signaling pathways involved in Ewing sarcoma, improving outcomes for patients.
How similar studies have performed: Other research has shown promise in targeting proteoglycan signaling in various cancers, suggesting that this approach could be effective in Ewing sarcoma as well.
Where this research is happening
Los Angeles, United States
- Children's Hospital of Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Vasileva, Elena — Children's Hospital of Los Angeles
- Study coordinator: Vasileva, Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.