Investigating the role of ETV6 in Ewing sarcoma treatment
Function and Targeting of ETV6 in Ewing Sarcoma
This study is looking at how a specific protein called ETV6 helps Ewing sarcoma cells survive, with the hope of finding new treatments for kids and young adults battling this tough bone cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11111471 on NIH RePORTER |
What this research studies
This research focuses on Ewing sarcoma, a severe bone cancer primarily affecting children and young adults, which currently has limited treatment options. The study aims to understand how the transcription factor ETV6 contributes to the survival of Ewing sarcoma cells and to explore potential therapies that target this factor. Using advanced techniques like CRISPR and single-cell transcriptomics, the researchers will analyze the effects of disrupting ETV6 on cancer cell behavior and differentiation. The goal is to develop more effective and specific treatments for patients suffering from this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults diagnosed with Ewing sarcoma.
Not a fit: Patients with other types of cancers or those who do not have Ewing sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for Ewing sarcoma that significantly improve patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting specific dependencies in cancer cells, suggesting that this approach could be effective for Ewing sarcoma as well.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Gao, Yuan — Case Western Reserve University
- Study coordinator: Gao, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.