Investigating the role of ETV6 in Ewing sarcoma treatment
Official title: Function and Targeting of ETV6 in Ewing Sarcoma
Funded at Case Western Reserve University · NIH-11111471 · Data updated 2026-11-12
This study is looking at how a specific protein called ETV6 helps Ewing sarcoma cells survive, with the hope of finding new treatments for kids and young adults battling this tough bone cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00CA273523-02 |
| Project ID | NIH-11111471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with Ewing sarcoma.
✕Less likely to help
Patients with other types of cancers or those who do not have Ewing sarcoma may not benefit from this research.
What this research studies
This research focuses on Ewing sarcoma, a severe bone cancer primarily affecting children and young adults, which currently has limited treatment options. The study aims to understand how the transcription factor ETV6 contributes to the survival of Ewing sarcoma cells and to explore potential therapies that target this factor. Using advanced techniques like CRISPR and single-cell transcriptomics, the researchers will analyze the effects of disrupting ETV6 on cancer cell behavior and differentiation. The goal is to develop more effective and specific treatments for patients suffering from this aggressive cancer.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for Ewing sarcoma that significantly improve patient outcomes.
How similar studies have gone: Previous research has shown promise in targeting specific dependencies in cancer cells, suggesting that this approach could be effective for Ewing sarcoma as well.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Gao, Yuan — Case Western Reserve University
- Study coordinator: Gao, Yuan
Related research
Other NIH-funded projects on the same topics.
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AI-powered prognostic model for Ewing sarcoma using digital pathology
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RAPID: A patient-centered, fast-tracked drug trial platform for young people with relapsed Ewing sarcoma and DSRCT
A patient-friendly, open-label phase 2 platform trial tests promising drug combinations for teens and young adults whose Ewing sarcoma or DSRCT has come back or not responded to treatment.
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TGFβ brakes immune evasion and metastasis in Ewing sarcoma during radiation
A physician-scientist will study whether blocking TGFβ during radiation can help CAR T cells fight Ewing sarcoma and improve patient outcomes.
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Function and Targeting of ETV6 in Ewing Sarcoma
A scientist at Case Western Reserve University is studying a specific protein, ETV6, that helps a rare bone cancer called Ewing sarcoma, with the goal of finding targeted therapies that could spare healthy cells.
-
Targeting immune markers in Ewing Sarcoma to guide safer, more effective therapies
A funded project at Stanford aims to use immune markers on Ewing Sarcoma to develop targeted immunotherapies that work in children and adults with this cancer.
-
Ewing sarcoma: how DNA repair weaknesses affect risk and treatment
A clinician-researcher team at Dana-Farber is studying how DNA damage repair weaknesses help drive Ewing sarcoma in kids and teens, with the goal of better predicting risk and guiding therapy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.