Investigating how Caveolin-1 influences Ewing Sarcoma cell behavior
Official title: The context-dependent role of Caveolin-1 as a driver of cellular adaptation in Ewing Sarcoma
Funded at Ut Southwestern Medical Center · NIH-10929361 · Data updated 2026-11-12
This study is looking at how a protein called Caveolin-1 affects the way Ewing Sarcoma cells, a type of cancer that mostly affects kids, adapt and grow in their environment, which could help us understand why this cancer can be tough to treat.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $150,444 |
| NIH project number | 5K99CA270285-02 |
| Project ID | NIH-10929361 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with Ewing Sarcoma.
✕Less likely to help
Patients with other types of cancers or those who do not have Ewing Sarcoma may not benefit from this research.
What this research studies
This research focuses on understanding how non-genetic factors, particularly the protein Caveolin-1, affect the adaptability of Ewing Sarcoma cells, a type of cancer primarily affecting children. The study employs advanced imaging techniques and zebrafish models to analyze how these cancer cells respond to their environment and how this may contribute to their growth and resistance to treatment. By exploring the role of Caveolin-1 in cellular signaling and adaptation, the research aims to uncover new insights into the mechanisms behind cancer progression and treatment challenges.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating Ewing Sarcoma by targeting the mechanisms that allow cancer cells to adapt and resist therapies.
How similar studies have gone: Previous research has shown promise in understanding cancer cell plasticity and signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Segal, Dagan — Ut Southwestern Medical Center
- Study coordinator: Segal, Dagan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.