How viral infections affect people with chronic lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will recruit adults with physician-confirmed chronic airway disease and follow them for up to two years, collecting samples when participants are well and again during flare-ups. Participants will provide self-collected nose swabs, finger-prick samples, and sputum at the start of an exacerbation and then attend a clinic visit for blood tests and further swabs. The prospective, closely monitored design aims to detect viruses early in exacerbations and compare viral presence and immune response between baseline and flare periods. Results are intended to clarify the role of respiratory viruses in driving exacerbations and inform future treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria.

AND

\- Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids).

Exclusion Criteria:

* Inability to complete daily symptom diaries and/or attend for clinical assessments.
* Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment.
* Pregnancy.

Where it's running

• Royal Brompton Hospital
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Anand Shah — Imperial College London
• Study coordinator: Patrick Senior
• Email: senior.patrick@gmail.com
• Phone: 004402075895111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.