Dupilumab in COPD: Real-world Registry of Outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The STRIDE Registry is an observational study enrolling about 350 COPD patients newly started on dupilumab across roughly 20 U.S. sites. Over about 2 years, researchers will collect data, chest images, and home spirometry to describe patient characteristics and safety, and to compare outcomes with a non-dupilumab external control cohort from PCORnet. The study aims to see if dupilumab reduces moderate to severe COPD exacerbations, improves lung function, and enhances quality of life in real-world practice. Participant management and treatment decisions are determined by patients and their healthcare providers. Chest imaging will be banked for future research, and homespirometry will be performed by consenting participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* COPD patients who are newly referred to start dupilumab treatment
* Age ≥ 40 years
* Standard of care spirometry performed concurrently with the baseline visit or within 90 days prior to the baseline visit

Exclusion Criteria:

* Patients who have contraindication to dupilumab according to the United States Prescribing Information (USPI)
* Any condition that, in the opinion of the Investigator, may interfere with the patient's ability to participate in the study, such as short life expectancy, or other comorbidities that can predictably prevent the patient from completing the schedule of assessments
* Patients currently participating in any interventional clinical trial The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial

Where it's running

• IU Health Pulmonology & Critical Care Medicine
  Indianapolis, Indiana, United States Recruiting
• University of Kansas
  Lawrence, Kansas, United States Recruiting
• Duke
  Durham, North Carolina, United States Recruiting
• Ohio State University
  Columbus, Ohio, United States Recruiting
• The Respire Institute
  Houston, Texas, United States Recruiting
• Activian Clinical Research
  Kingwood, Texas, United States Recruiting

Study contacts

• Study coordinator: Trial Transparency Trial Transparency
• Email: Contact-us@sanofi.com
• Phone: 800-633-1610 option 6

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.