See if chest CT and biological data can tell asthma from COPD and predict treatment response
Official title: Prospective Multicenter Cohort to Discriminate Asthma Versus Chronic Obstructive Pulmonary Disease and Predict Treatment Response Using Quantitative Chest CT and Multi-Omics
Run by Korea University Guro Hospital · NCT07602192 · Data updated 2026-11-12
Researchers will test whether combining chest CT measurements with biological data can distinguish asthma from COPD and predict how patients will respond to standard treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Korea University Guro Hospital Academic / other |
| Locations | 2 sites (Seoul, Dongjak-gu and 1 other locations) |
| Status | Recruiting |
| Started | December 22, 2025 |
| Main results expected | November 30, 2027 |
| Study ends | December 22, 2027 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT07602192 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (19+) diagnosed with asthma or COPD who are willing to participate in longitudinal follow-up and can undergo chest CT and standard evaluations.
✕Probably not a fit
Patients who do not have asthma or COPD or who cannot complete follow-up or CT imaging may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, multi-center observational study enrolling adults with asthma or COPD. Participants undergo routine clinical assessments, pulmonary function tests, blood tests, and chest CT scans, with optional sputum and microbiome sampling when feasible. Imaging features will be analyzed alongside clinical, laboratory, and microbiome data to identify signatures that differentiate asthma from COPD and to see if these signatures predict treatment responses. No experimental drugs or devices are used; the study relies on standard care procedures. Advanced statistical methods will integrate multi-omics with imaging to improve personalized management of chronic airway disease.
Why it matters
Potential benefit: If successful, the study could lead to more accurate diagnosis and better forecasts of how patients will respond to treatments.
How similar studies have gone: Other studies have shown that imaging and biological data can help differentiate airway diseases and predict treatment responses, though integration at this scale is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥19 years * COPD group: post-bronchodilator FEV1/FVC \< 0.70 * Asthma group: clinically confirmed diagnosis of asthma by a physician * Able to provide voluntary written informed consent Exclusion Criteria: * Acute exacerbation or active lower respiratory tract infection (e.g., pneumonia) within the past 4 weeks * Pregnancy or breastfeeding * Inability to undergo chest CT (e.g., poor cooperation or severe medical condition) * Refusal to consent to study procedures
Where it's running
-
SMG-SNU Boramae Medical Center
Seoul, Dongjak-gu, South Korea Recruiting -
Korea University Guro Hospital
Seoul, Guro-gu, South Korea Recruiting
Study contacts
- Principal investigator: Sang Hyuk Kim, MD — Korea University Guro Hospital
- Study coordinator: Sang Hyuk Kim, MD
- Email: gost702@korea.ac.kr
- Phone: +82-2-2626-1659
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.