Pulmonary and Total Blood Volume in COPD: Do COPD patients have lower pulmonary blood volume relative to total blood volume than healthy adults?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares COPD patients (GOLD I–III) with matched healthy controls to see if pulmonary blood volume relative to total blood volume is reduced. Participants are 45–80 years old with specific inclusion/exclusion criteria, and no intervention is applied. Data will be analyzed using R to determine if there is a statistically significant difference in the ratio of pulmonary to total blood volume between groups. The study aims to shed light on a potential mechanism linking reduced exercise capacity to vascular changes in COPD. Results could inform future research on disease mechanisms and targets for therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion criteria -patients

  * Men and women
  * 45-80 years
  * COPD (GOLD stage I to III)
  * Resting arterial oxygenation \> 90% Inclusion criteria - controls
  * Men and women
  * 45-80 years
  * Normal FEV1, FVC, FEV1/FVC, and single-breath diffusion capacity
  * Same sex, age (± 3 years) and height (± 5 cm) as an included COPD patient
  * Low- to moderate activity level defined as \< 1,5 hours of structured physical activity pr. week at moderate intensity and cycling \< 30 minutes/5km pr. day at moderate intensity (moderate intensity = out of breath but able to speak)

Exclusion Criteria:

Exclusion criteria - patients

* Symptoms of ischaemic heart disease
* Known heart failure
* Previous severe or current COVID-19
* Claudication
* Symptoms of disease within 2 weeks prior to the study
* Participation in pulmonary rehabilitation within 6 months
* Known malignant disease
* Pregnancy
* Unstable cardiac arrhythmic disease
* Renal or liver dysfunction

Exclusion criteria - controls

* Known chronic lung disease
* Known ischaemic heart disease
* Known heart failure
* Previous severe or current COVID-19
* Symptoms of disease within 2 weeks prior to the study
* Known malignant disease
* Claudication
* Pregnancy
* Unstable cardiac arrhythmic disease
* Renal or liver dysfunction

Where it's running

• Center for Aktiv Sundhed
  Copenhagen, Denmark Recruiting

Study contacts

• Study coordinator: Ronan MG Berg, MD, DMSc
• Email: ronan@sund.ku.dk
• Phone: 004535451825

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.