Condition

ALS (Amyotrophic Lateral Sclerosis) clinical trials and research

• 24Clinical trials
• 1New in 30 days
• 16Countries

Newest ALS (Amyotrophic Lateral Sclerosis) clinical trials

All recruiting trials (24)

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Imaging markers for bulbar involvement in inclusion body myositis among IBM and comparison groups

  This study tests whether ultrasound and MRI can detect swallowing and bulbar muscle problems in people with inclusion body myositis.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07823101

• 7T MRI Pilot to Find Imaging Biomarkers in ALS and related motor neuron diseases

  A 7T MRI study is being done to see if ultra-high-field brain scans can reveal non-invasive biomarkers in adults with motor neuron disease, including ALS.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow · NCT07818772

• Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases

  This study collects blood and genetic samples from people with neurodegenerative diseases and their families to build a shared resource for studying disease risk and biology.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07798700

• Ultra-high-resolution PET imaging of aging, neurodegeneration, and psychotic disorders

  We will test whether ultra-high-resolution PET and 3T MRI scans can reveal early brain and spinal cord changes in healthy adults and people with Alzheimer's, Parkinson's disease, ALS, PSP, REM sleep behavior disorder, or psychotic disorders.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT07509125

• Use of invasive home ventilation in Denmark

  This project will see how often people with neuromuscular diseases or spinal cord injuries in Denmark used invasive home mechanical ventilation between 2016 and 2025 and what their one-year outcomes were.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07467187

• Measuring how assistive technologies and brain-computer interfaces help people use digital devices

  This project will test a Digital Assessment Interface to see if it can measure how well different assistive technologies and brain-computer interfaces help adults with spinal cord injury or ALS use computers, phones, and other digital systems.

  Recruiting Shirley Ryan AbilityLab · Chicago, Illinois · NCT07407725

• CTx1000 gene therapy delivered into the cisterna magna for people with ALS

  This trial will test a single-dose gene therapy called CTx1000 given into the cisterna magna to see if it is safe and tolerable for people with early ALS.

  Recruiting Phase 1 Celosia Therapeutics Pty Ltd · Sydney, New South Wales · NCT07401121

• Tongue-strengthening exercises for people with ALS

  This program will test whether daily tongue-strengthening exercises can help people with ALS maintain or improve speech and swallowing.

  Recruiting Nova Southeastern University · Davie, Florida · NCT07295990

• Tongue-strengthening exercises for people with ALS

  This program will test whether daily tongue-strengthening exercises can help people with ALS maintain or improve speech and swallowing.

  Recruiting Nova Southeastern University · Davie, Florida · NCT07295990

• Tofersen for adults with ALS who do not have SOD1 mutations

  This study will test whether tofersen given by lumbar puncture over 24 weeks lowers neurofilament light chain and is safe for adults with ALS who do not have SOD1 mutations.

  Recruiting at 3 sites Phase 2 Washington University School of Medicine · Atlanta, Georgia and 2 other locations · NCT07294144

• Omics-based profiling to find disease mechanisms and biomarkers in Alzheimer’s, Parkinson’s, FTD, and related dementias

  This project will use advanced omics tests (genetics, gene expression, proteins, and metabolites) to try to find biological markers and disease mechanisms in people with Alzheimer’s, Parkinson’s, frontotemporal and young-onset dementias, or mild cognitive impairment.

  Recruiting Ospedale Policlinico San Martino · Genoa, Genoa · NCT07235111

• Thailand ALS Patient Registry

  This registry will collect detailed clinical, genetic, and outcome information from adults with ALS across Thailand to track disease progression and treatment results.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07175935

• LY4256984 for people with sporadic ALS.

  This trial will test LY4256984 given into the spine to see how safe it is and how it behaves in the body for people with sporadic ALS.

  Recruiting at 10 sites Phase 1 Eli Lilly and Company · Leuven and 11 other locations · NCT07100119

• CB03-154: testing different doses for adults with ALS

  This trial tests whether CB03-154 can help adults with ALS by delaying progression and improving function compared with a placebo.

  Recruiting Phase 2/3 Shanghai Zhimeng Biopharma, Inc. · Beijing, Beijing Municipality · NCT07082192

• Personalized rTMS plus mixed-reality exercise for people with motor neuron disease

  This trial tests whether combining personalized rTMS with mixed-reality exercise games can slow disease progression and improve daily function in adults with mild-to-moderate motor neuron disease.

  Recruiting Chulalongkorn University · Bangkok, Pathumwan · NCT07067229

• At-home cortico-spinal tDCS for ALS.

  This treatment tests whether daily at-home cortico-spinal tDCS can slow nerve damage and symptoms in adults with early ALS.

  Recruiting University of Trieste · Trieste, Trieste · NCT07006571

• Observational study on amyotrophic lateral sclerosis

  This study is collecting health information from people with ALS, those with related genetic mutations, and healthy volunteers to help improve treatments and understand the disease better.

  Recruiting ALS Therapy Development Institute · Watertown, Massachusetts · NCT06885918

• Using augmented reality to improve communication for late stage ALS patients

  This study is testing a new augmented reality device to see if it can help people with late stage ALS communicate better and more easily.

  Recruiting Cognixion · Santa Barbara, California · NCT06810219

• Psilocybin therapy for depression and existential distress in people with COPD, ALS, MS, or atypical Parkinson disease

  This trial will test whether psilocybin therapy can reduce depression and psychological distress in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least six months expected life.

  Recruiting at 4 sites Phase 2 University Medical Center Groningen · Prague and 3 other locations · NCT06782724

• Non-invasive treatment for ALS using MyoRegulator® device

  This study is testing whether the MyoRegulator® device can safely help people with ALS improve their movement and slow down the progression of the disease.

  Recruiting PathMaker Neurosystems Inc. · Boston, Massachusetts · NCT06649955

• Impact of Probiotics on Patients with ALS and Frontotemporal Dementia

  This study is testing if a probiotic supplement can help people with ALS and frontotemporal dementia feel better and improve their health compared to those who get a placebo.

  Recruiting at 3 sites Centre hospitalier de l'Université de Montréal (CHUM) · Fredericton, New Brunswick and 2 other locations · NCT06051123

• Identifying biomarkers for early diagnosis of motor neuron diseases

  This study is trying to find new ways to diagnose motor neuron diseases early by looking at brain and muscle signals in patients to help improve their care.

  Recruiting University of Dublin, Trinity College · Dublin, Leinster · NCT05663008

• A study on early diagnosis and biomarkers for dementia and related diseases

  This study is testing new ways to spot dementia and related diseases early by looking for specific markers in the brain and body, to help people at high risk and track how well new treatments are working.

  Recruiting at 2 sites Skane University Hospital · Ängelholm and 1 other locations · NCT03174938

Related topics

Quick answers

How many ALS (Amyotrophic Lateral Sclerosis) clinical trials are recruiting right now?

24, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (9 trials), Italy (2 trials), Thailand (2 trials), Germany (2 trials), Belgium (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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