New breathing tests to diagnose airway disease in hospital and community settings

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares newer lung tests with standard spirometry to see if they can identify airway disease as accurately, earlier, and more conveniently. It includes adults with suspected COPD or airway disease who are referred to hospital or community services, and collects data on test performance, practicality, and cost. The research will be conducted in clinical settings across multiple NHS sites, with attention to patient comfort and ease of use. No interventions are imposed beyond standard testing plus the additional breathing assessments being evaluated. Results could inform whether simpler, cheaper tests can complement or replace some aspects of current diagnostic pathways.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 18 years of age
* New referral to community or secondary healthcare services
* Clinical suspicion of airway disease/COPD
* Able to provide fully informed written consent
* Able to fully understand and cooperate with the study protocol
* Clinically stable with no contraindications to lung function testing (outlined below)

Exclusion Criteria:

* Confirmed diagnosis of COPD
* Not willing and/or able to provide fully informed written consent to participate
* Has a relative contraindication to lung function testing \[18\]:
* Recent thoracic, abdominal or eye (e.g. cataract) surgery \< 6 weeks
* Unstable cardiovascular status, including recent myocardial infarction or pulmonary embolus \< 6 weeks
* Pneumothorax \< 6 weeks
* Haemoptysis of unknown origin \< 6 weeks
* Thoracic, abdominal or cerebral aneurysm
* Chest infection \< 6 weeks
* An acute illness or symptom that might interfere with test performance (e.g. nausea, vomiting).
* The presence of any other clinical condition that would prevent the individual from safely performing lung function tests

Where it's running

• Hampshire Hospitals NHS Foundation Trust
  Andover, Hampshire, United Kingdom Recruiting
• University Hospital Southampton NHS Foundation Trust
  Southampton, Hampshire, United Kingdom Not yet recruiting

Study contacts

• Study coordinator: Professor Tom M Wilkinson, MBBS PhD FRCP FERS
• Email: t.wilkinson@soton.ac.uk
• Phone: 02381205341

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.