High-Flow Nasal Cannula vs Noninvasive Ventilation in COPD with Hypercapnia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two noninvasive respiratory support methods in adults hospitalized for COPD with mild-to-moderate hypercapnic respiratory failure. Patients are randomized or otherwise allocated to receive either high-flow nasal cannula or noninvasive ventilation to monitor gas exchange trends, clinical outcomes, and tolerability. The trial aims to determine which approach provides better physiological improvement and patient experience. It excludes patients with severe acidosis, instability, or conditions that could confound outcomes, ensuring a focus on tolerability and efficacy in this specific COPD subset. Conducted at the Faculty of Medicine, Mansoura University, under lead sponsor Mohammed Shehta, the study evaluates practical applicability of HFNC in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* COPD patients hospitalized with mild-to-moderate hypercapnic respiratory failure, defined as arterial pH \[range, e.g., 7.25-7.35\] and PaCO2 \[threshold, e.g., \>45 mmHg and less 60 mmHg\].

Exclusion Criteria:

* patients with altered mental state, confused, severe agitation or not cooperative were excluded. Also, severe acidosis (pH \<7.25), hemodynamic instability, facial trauma or surgery, cases with severe nasal deformity, immediate indication for invasive ventilation, patient refusal, cases with respiratory rate more than 35 breaths per minute. Respiratory exhaustion, excess use of respiratory accessory muscles, Patients with breathing disorders during sleep as well as cases of upper airway obstruction and patients with history of chronic home ventilation prior admission were another items for exclusion

Where it's running

• Faculty of Medicine, Mansoura University
  Al Mansurah, Dakahlia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Mohammed Shehta, associate professor-chest med.
• Email: dr_mshehta@mans.edu.eg
• Phone: 01004344106

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.