Condition

Cognitive Function clinical trials and research

• 23Clinical trials
• 126NIH research projects
• 15Countries

Newest Cognitive Function clinical trials

All recruiting trials (23)

• Omega-3 Fatty Acids and Red Blood Cell Membranes in Competitive Soccer Players

  This study tests whether high-dose omega-3 supplements change red blood cell membranes and may affect performance and cognition in competitive male soccer players aged 16–35.

  Recruiting The Jerzy Kukuczka Academy of Physical Education in Katowice · Katowice, Mikolowska 72a · NCT07768423

• Binaural beats for cognitive function in older adults with mild cognitive impairment in nursing homes

  This study tests whether listening to 10-Hz binaural beats for 30 minutes daily for 14 days can help cognitive function in older adults with mild cognitive impairment living in nursing homes.

  Recruiting at 3 sites China Medical University, China · Shenyang, Liaoning and 2 other locations · NCT07735910

• Diet, Fat Quality, and How Your Body Responds to Exercise

  This observation study tests whether your usual fat quality in diet and metabolic health relate to how you feel during and after exercise, plus your cognitive function and school-related engagement.

  Recruiting University of Wisconsin, River Falls · River Falls, Wisconsin · NCT07728240

• Foot arch shape and its link to walking speed, gait timing, and leg reaction time in older adults

  See if foot arch shape relates to walking speed, gait timing, and leg reaction time in people aged 65 and older.

  Recruiting Balikesir University · Balıkesir, Bigadiç · NCT07582367

• Safety and how AP-Brain affects thinking in healthy young adults with self-reported attention problems

  This study tests whether AP-Brain at 1g, 3g, or 5g can improve cognitive function compared with placebo in healthy adults aged 18–39 who report attention problems.

  Recruiting Rousselot BVBA · London, Ontario and 1 other locations · NCT07388576

• Home-based inspiratory muscle training to lower dementia risk in older adults

  This study will test whether an 8-week, daily home inspiratory breathing program can lower blood pressure and improve thinking, mood, and sleep in adults aged 60–80 who have risk factors for dementia.

  Recruiting Florida State University · Tallahassee, Florida · NCT07349706

• B-vitamins plus omega-3s to reduce brain atrophy markers

  We will test whether taking B‑vitamins together with a highly absorbable omega‑3 supplement lowers a blood marker of brain atrophy in adults over 65 who have low B‑vitamin status.

  Recruiting University of Oslo · Oslo · NCT07312435

• Plant versus animal protein supplements to improve brain blood flow, insulin response, thinking, and appetite in older adults

  This tests whether two weeks of a daily plant or animal protein supplement can improve brain blood flow, brain insulin response, thinking, and appetite control in overweight or obese adults aged 60–75.

  Recruiting Maastricht University Medical Center · Maastricht, Limburg · NCT07057245

• Phospholipid-rich dairy extract for mild memory problems

  This will test whether taking a daily phospholipid-rich dairy milk extract for 12 weeks helps adults aged 55–85 with mild cognitive impairment think and remember better and whether it is safe.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT07011680

• Daily spice consumption and its effects on memory function

  This study is testing whether taking a daily spice capsule can help improve memory in older adults with mild cognitive decline.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT06889961

• Muscle loss in pregnant women with gestational diabetes.

  This project will test whether pregnant women with gestational diabetes show signs of muscle loss (sarcopenia) and whether those muscle measures relate to pregnancy outcomes and thinking skills.

  Recruiting at 2 sites Istituto di Neuroscienze Consiglio Nazionale delle Ricerche · Vienna and 2 other locations · NCT06876090

• Exploring how sleep quality affects self-care in heart failure patients

  This study looks at how the quality of sleep affects self-care habits in people with heart failure over six months.

  Recruiting Dokuz Eylul University · Izmir · NCT06747689

• Dose effects of CitraPeak (glucosyl‑hesperidin) on exercise, blood flow, stress, and thinking

  This test tries daily CitraPeak (glucosyl‑hesperidin) at two doses to see if it helps healthy, recreationally active adults (18–50) improve exercise performance, recovery, blood flow, mood, and cognition.

  Recruiting Lindenwood University · Saint Charles, Missouri · NCT06672952

• Examining motor imagery and cognitive functions in people with Type 2 Diabetes

  This study tests how well people with Type 2 Diabetes can imagine movements and how that relates to their thinking skills and body awareness.

  Recruiting Kutahya Health Sciences University · Kütahya, Central · NCT06588894

• Exploring mental health and psychosomatic factors from childhood to adulthood

  This study looks at how childhood experiences can impact mental and physical health as people grow up, involving students, parents, and teachers from different schools in China.

  Recruiting Peking University · Beijing, Beijing Municipality · NCT05621278

• Virtual reality exercise program for women veterans

  This study is testing a new virtual reality exercise program to see if it can help women veterans improve their physical and mental health over eight weeks.

  Recruiting The University of Texas at Arlington · Arlington, Texas · NCT05563805

• Effects of brain stimulation on cognitive task performance

  This study tests if a type of brain stimulation can help improve attention, learning, and memory in people while they do thinking tasks.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT05556655

• Registration of patients with narrowing of brain or neck arteries

  This study is looking to see how narrowing in brain or neck arteries affects thinking and memory in people aged 40 and older.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05322824

• Exploring the links between sleep hygiene, muscle loss, and brain function in lung disease

  This study looks at how good or bad sleep affects muscle loss and brain function in people with lung diseases like COPD and IPF.

  Recruiting National Hospital Organization Minami Kyoto Hospital · Jōyō, Kyoto · NCT05193136

• Comparing high-intensity and moderate-intensity exercise during pregnancy and its effects on health and birth outcomes

  This study tests whether high-intensity or moderate-intensity exercise during pregnancy can improve health and birth outcomes for moms and their babies.

  Recruiting Gdansk University of Physical Education and Sport · Gdansk, Pomeranian Voivodeship · NCT05009433

• Investigating brain activity in epilepsy patients using implanted electrodes

  This study is testing how brain activity in patients with hard-to-treat epilepsy can help us understand their seizures and how it affects their thinking and sleep.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT04653012

• Effects of Gadolinium-based Contrast Media on Movement and Mental Skills

  This study is testing how repeated use of gadolinium-based contrast agents during imaging tests affects movement and thinking skills in healthy adults.

  Recruiting at 25 sites Phase 4 Guerbet · Scottsdale, Arizona and 50 other locations · NCT04373564

• Investigating brain health in breast cancer survivors undergoing hormone therapy

  This study is trying to see how hormone therapy affects brain function in breast cancer survivors, especially looking at how menopause plays a role.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT04297020

NIH-funded research (newest 40 of 126)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How specific anti-NMDAR1 antibodies in the blood may affect memory and brain protection

  This research is exploring whether natural or abnormal anti-NMDAR1 antibodies in the blood influence memory, behavior, and brain protection in humans.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11617810

• Mexican Teachers Cohort Study: Genetics and Cognitive Function

  A large study using genetic data from Mexican teachers to discover genetic factors linked to memory and thinking in older adults.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11595537

• Genetics and Cognitive Function in Mexican Teachers Cohort for Alzheimer’s Dementia

  This grant funds a large study to find genetic factors linked to memory and thinking in Mexican teachers, with the goal of improving understanding of Alzheimer’s-related dementia.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11595536

• How childhood nutrition affects health, thinking, and life outcomes by middle age

  This project compares people who got extra nutrition as children with those who did not to understand differences in health, thinking, and life outcomes in middle age.

  NIH research Emory University · Atlanta, United States · NIH-11515104

• How the brain receptor mGlu1 affects thinking after teen cocaine exposure

  This project looks at whether boosting mGlu1 receptor activity can restore brain inhibition and improve memory and flexible thinking after cocaine use during the teen years.

  NIH research Emory University · Atlanta, United States · NIH-11473570

• Canagliflozin to protect the aging brain and improve cognition in Alzheimer’s disease

  Aging is linked to Alzheimer’s and this project tests whether the diabetes drug canagliflozin can help brain function and reduce inflammation in older adults with or at risk for Alzheimer’s/dementia.

  NIH research Wayne State University · Detroit, United States · NIH-11463471

• Aortic stiffness and brain health: how arterial pulses affect dementia risk

  This project looks at whether stiffer arteries and pulsing blood flow are linked to brain small vessel damage and changes in thinking in middle-aged adults.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11463277

• Mitochondrial Calcium Sensing in Aging and Memory with TUSC2

  A small mitochondrial protein called TUSC2 may help protect brain cells from aging-related cognitive decline by keeping mitochondria functioning properly.

  NIH research Meharry Medical College · Nashville, United States · NIH-11454540

• Childhood Trauma and Aging: How Early Stress Shapes Midlife Health

  This project looks at how childhood abuse and stress may speed up aging in the body and affect thinking skills by midlife, using data from a large national study.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11449548

• Precision brain stimulation to restore thinking and memory across multiple conditions

  A wide-range study uses targeted brain stimulation to improve memory and thinking in models of Alzheimer’s, autism, and related disorders.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11416621

• Sex differences in high blood pressure, thinking skills, and kidney function tied to B cells and autoantibodies

  This research looks at how sex and pregnancy-related antibodies may influence high blood pressure, thinking abilities, and kidney blood flow in adults.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11416476

• Genetics and Cognitive Function in Mexican Teachers Cohort

  A large study will add genetic and brain-health data from Mexican teachers to enhance understanding of how genes influence memory and thinking as people age.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11403857

• Nosocomial pneumonias and cognitive function in ICU survivors

  In ICU survivors, this project looks at how pneumonia acquired in the hospital may be linked to long-term thinking and memory problems.

  NIH research University of South Alabama · Mobile, United States · NIH-11401992

• Understanding how daily activity patterns affect memory and dementia risk

  This project looks at how a full day of activities – including sleep, light and moderate exercise, and sitting time – might influence thinking skills and the chance of developing Alzheimer’s disease or related dementias.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11399326

• Cognitive Function and Dementia in South Africa: A Longitudinal Study

  A long-term study in South Africa aims to understand how dementia develops and affects people as they age, using harmonized surveys and biomarkers so findings can help people in similar settings.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11399312

• How stress, body wear, and neighborhoods affect thinking in midlife and older adults

  This project looks at how chronic stress and neighborhood conditions may influence thinking skills over time in adults aged 50 and up.

  NIH research Xavier University of Louisiana · New Orleans, United States · NIH-11399049

• Thinking skills and self-care after a liver transplant

  This project follows people who received liver transplants to learn how changes in thinking and memory affect managing medicines, clinic visits, and overall health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11398886

• Aging fat cells and their impact on memory and Alzheimer's disease

  Researchers are looking at whether aged, harmful cells in body fat send signals that damage the brain and speed memory loss in people at risk for Alzheimer's.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11397887

• Tip60 histone acetyltransferase and brain health in Alzheimer’s disease

  This NIH grant explores how a brain enzyme called Tip60 helps protect memory and cognitive function in Alzheimer-like conditions using a fruit fly model and neural studies.

  NIH research Drexel University · Philadelphia, United States · NIH-11397592

• Mexican Teachers Cohort — genes and memory in older adults

  This project uses DNA and thinking-test information from mostly older Mexican women to find genes linked to memory and dementia.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11384675

• Genetics and memory in Mexican teachers

  This project looks at how genes relate to memory and thinking in older Mexican teachers by adding their genetic data to a large Alzheimer's research effort.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11384674

• Protective and Risk Factors for Cognitive Function in the Menopause Transition

  This grant explores how lifestyle, sleep, and cardiometabolic factors affect thinking and memory during menopause to help women maintain cognitive health.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-11372877

• Helping people with heart failure and mild thinking problems manage their care through mindfulness and body-awareness

  This project teaches mindfulness and attention skills to help people with heart failure and mild thinking problems notice symptoms and follow medicines and lifestyle advice more reliably.

  NIH research Miriam Hospital · Providence, United States · NIH-11372024

• SARS-CoV-2, APOE, and dementia: how COVID-19 affects thinking in aging and Alzheimer’s

  This NIH grant explores how COVID-19 may impact brain function and pathology in people with aging or Alzheimer's disease, including how APOE genes might influence the effects.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11370014

• Oxytocin Treatment and Thinking Skills in Fragile X

  This work explores if early oxytocin treatment can improve memory and thinking skills in a model of Fragile X Syndrome, which is related to autism.

  NIH research University of California-Irvine · Irvine, United States · NIH-11369018

• Astrocyte RNA degradation and its link to thinking and memory

  Researchers are studying how a brain cell support system called astrocytes affects memory and thinking by controlling mRNA stability through a process called NMD.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11364192

• Health literacy and cognitive function in midlife adults

  A study in adults aged 35–64 will look at how health literacy and self-management relate to early changes in thinking and memory to help prevent Alzheimer’s and related dementias.

  NIH research Northwestern University · Chicago, United States · NIH-11361751

• Remotely delivered brain stimulation to help cognition in Veterans with mTBI and PTSD

  A non-invasive brain stimulation treatment used at home aims to improve thinking skills for Veterans who have had mild brain injuries and PTSD.

  NIH research Philadelphia VA Medical Center · Philadelphia, United States · NIH-11346972

• Understanding how sleep problems in older couples relate to thinking skills and Alzheimer's risk

  This project looks at how insomnia in older couples may influence memory and thinking over time, with the goal of better understanding Alzheimer’s disease progression.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11333382

• High-Intensity Exercise to Protect Cognition and Build Exercise Habits in Older Adults Living with HIV

  A funded program tests whether 4 months of HIIT can help older people with HIV improve cognitive function and stick with regular exercise better than standard moderate exercise.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11332468

• Gpld1, a blood protein that may boost brain regeneration and memory in aging

  This project checks if raising levels of a blood protein called Gpld1 can improve brain cell renewal and memory in older adults and people with Alzheimer's-type dementia.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11325382

• Hippocampal neurogenesis and its link to memory in Alzheimer’s disease

  This study investigates whether new brain cells form in the hippocampus of people with Alzheimer’s and how this may relate to memory and cognitive decline.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11325347

• How air quality and neighborhood design affect thinking and social connection in rural older adults

  This project uses wearables and daily surveys to look at whether air pollution, local neighborhood features, and social isolation affect thinking and memory in middle-aged and older rural adults.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-11311345

• How couples' sleep and daily routines affect memory and Alzheimer's risk

  This project explores whether shared sleep patterns and daily routines between older adults with mild cognitive problems and their partners influence memory and future Alzheimer's risk.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11311288

• Personalized diets based on gut microbes to help prevent Alzheimer's

  Seeing if tailoring healthy diets to a person's gut microbes can help protect thinking and memory in older adults at risk for Alzheimer's.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11308277

• How childhood nutrition shapes health, thinking, and economic life into middle age

  Researchers are following people who took part in a childhood nutrition program to learn how that nutrition links to health, thinking, and income in middle age.

  NIH research Emory University · Atlanta, United States · NIH-11308228

• Adaptive computerized test for memory, thinking, and attention

  This project builds a short, computer-based test for adults that measures memory, language, attention, processing speed, and reasoning to help spot early changes in thinking.

  NIH research University of Chicago · Chicago, United States · NIH-11307617

• Clearing toxic tau by boosting mitochondrial cleanup to protect memory and brain connections

  This project boosts a natural mitochondrial cleanup protein called PINK1 to try to remove toxic tau and protect memory and brain connections for people with Alzheimer’s.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11297677

• Understanding COVID-19's Effects on Brain Health in Aging and Alzheimer's Disease

  This project looks at how COVID-19 affects thinking and brain health over time, especially in older adults and those with a gene linked to Alzheimer's.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11297471

• Sleep brain-wave tracking for overnight brain changes and morning thinking

  Researchers are using nighttime brain-wave recordings to see how night-to-night changes and things like sleep loss, shiftwork, or caffeine affect morning thinking in adults.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11293020

Related topics

Quick answers

How many Cognitive Function clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (8 trials), China (3 trials), Turkey (Türkiye) (3 trials), Italy (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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