NIH-funded research NIH-funded research

High-Intensity Exercise to Protect Cognition and Build Exercise Habits in Older Adults Living with HIV

Official title: Examining the Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living with HIV (HEALTH-Cog)

Funded at University of Alabama at Birmingham · NIH-11332468 · Data updated 2026-11-12

A funded program tests whether 4 months of HIIT can help older people with HIV improve cognitive function and stick with regular exercise better than standard moderate exercise.

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Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Alabama at Birmingham
NIH-funded
Lab location1 site (Birmingham, United States)
Project startMay 15, 2023
Project endApril 30, 2028
Funding year2026
Award (this year)$1,350,378
NIH project number4RF1AG077997-04
Project IDNIH-11332468 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are adults aged 50 and older living with HIV who can participate in supervised HIIT or CME and are able to engage with text-message reminders.

Less likely to help

Individuals who cannot safely participate in high-intensity exercise or who have contraindications to physical activity may not benefit.

What this research studies

This project recruits older adults with HIV to participate in a two-site randomized trial comparing high-intensity interval training to continuous moderate exercise, followed by a 3-month text-message reminder to support ongoing activity. Researchers will measure physical function, fatigue, and cognitive outcomes to see if the HIIT approach provides greater benefits. The study aims to identify how to create durable exercise habits that protect brain health as people aging with HIV face higher risks of dementia-related conditions. Results could guide future programs that combine effective workouts with behavioral support for sustained activity.

Why it matters

Potential benefit: If successful, the program could improve cognitive health and physical well-being for older adults living with HIV by promoting lasting exercise habits.

How similar studies have gone: Prior studies suggest exercise can influence cognitive and physical health, but this trial tests a specific HIIT approach plus adherence support in older adults with HIV.

Where this research is happening

  • University of Alabama at Birmingham
    Birmingham, United States
    Active

Researchers

  • Principal investigator: Wheeler, Pariya Fazeli — University of Alabama at Birmingham
  • Study coordinator: Wheeler, Pariya Fazeli

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.