Investigating brain health in breast cancer survivors undergoing hormone therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the effects of endocrine therapy on cognitive function in breast cancer survivors, particularly focusing on the role of menopausal status. By employing a cross-sectional, 2x2 factorial design, the study will compare brain activity between survivors on endocrine therapy and healthy controls using advanced fMRI techniques during a working memory task. The research seeks to address inconsistencies in previous studies by considering menopausal status and utilizing sensitive cognitive measures. The findings could provide insights into how hormone therapy impacts brain health in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 35-65
* Fluent in English
* Adequate vision/hearing to complete testing

Exclusion Criteria:

* History of major or mild neurocognitive disorder or dementia
* Diagnosis of major neurological condition (e.g., epilepsy, Parkinson's Disease, stroke)
* Diagnosis of a major psychiatric disorder (e.g., bipolar disorder, schizophrenia)
* Untreated/unstable unipolar depression or anxiety
* Prior history of cancer or chemotherapy (for controls, any history)
* History of a learning disorder
* History of head injury with loss of consciousness \>20 minutes
* History of salpingo-oophorectomy or hysterectomy
* A cardiac pacemaker
* Implanted electronic device
* Claustrophobia
* Currently pregnant
* Orbital metal implant or other metallic foreign bodies

Additional exclusion criteria for controls: current use of a contraceptive agent that interferes with endogenous hormonal fluctuation (e.g., oral contraceptive pill) or precludes determination of menstrual pattern (e.g., hormonally secreting intrauterine device), or current treatment with systemic estrogen replacement therapy.

Where it's running

• University of California at Los Angeles
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Kathleen Van Dyk, PhD — University of California at Los Angeles
• Study coordinator: Kathleen Van Dyk, PhD
• Email: KVanDyk@mednet.ucla.edu
• Phone: 310 825-2719

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.