How childhood nutrition affects health, thinking, and life outcomes by middle age

The impact of early-life nutrition on socioeconomic status, physical health and cognitive function through middle age

NIH-funded research Emory University · NIH-11515104

This project compares people who got extra nutrition as children with those who did not to understand differences in health, thinking, and life outcomes in middle age.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionEmory University NIH-funded
Lab location1 site (Atlanta, United States)
Project IDNIH-11515104 on NIH RePORTER

What this research studies

This project follows people who took part in a nutrition program in Guatemala that began in 1969 and compares those who received supplements as children with those who did not. Researchers will use decades of follow-up data and recent health and cognitive measures collected when participants are 47–64 years old to look at physical health, thinking skills, and socioeconomic outcomes. They will examine both current levels and changes from early adulthood to middle age to see how early nutrition shaped long-term aging. Because the original program randomly assigned supplementation, the results can more clearly link childhood nutrition to later-life outcomes.

Who could benefit from this research

Good fit: Ideal candidates are adults now in their late 40s to mid-60s who were participants in the original Guatemalan nutrition trial or had documented early-life nutrition interventions like it.

Not a fit: Young children, people outside the middle-age range, or those without documented early-life nutrition exposure are unlikely to directly benefit from participating in this specific project.

Why it matters

Potential benefit: If successful, this work could show whether improving childhood nutrition helps reduce age-related declines and inform programs that boost lifelong health and functioning.

How similar studies have performed: Prior research has linked childhood undernutrition to worse schooling, cognition, and earnings in early adulthood, but extending those findings into middle age using experimental long-term data is less common.

Where this research is happening

Atlanta, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.