Registration of patients with narrowing of brain or neck arteries
Clinical Registration Study of Patients With Intracranial / Carotid Stenosis
This study is looking to see how narrowing in brain or neck arteries affects thinking and memory in people aged 40 and older.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT05322824 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect and analyze data from patients aged 40 and older who have significant narrowing (≥ 50%) in their intracranial or carotid arteries. Participants will undergo standard medical treatment and may receive interventional stenting, while their clinical information, neuropsychological assessments, and multimodal MRI results will be documented. The goal is to identify cognitive impairments associated with these conditions early on, enhancing understanding and management of cognitive function in affected patients.
Who should consider this trial
Good fit: Ideal candidates are patients aged 40 and older with at least 50% stenosis in a unilateral intracranial or carotid artery.
Not a fit: Patients with a history of major head trauma, intracranial surgery, or severe sensory impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier identification and better management of cognitive impairments in patients with intracranial or carotid stenosis.
How similar studies have performed: While similar studies have explored cognitive function in vascular conditions, this specific approach focusing on early identification in a defined patient population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged ≥ 40 years * ≥ 50% stenosis in unilateral intracranial / carotid artery * Written informed consent available Exclusion Criteria: * Previous history of major head trauma and any intracranial surgery * Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions * Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement * Severe loss of vision, hearing, or communicative ability Exit Criteria: * Not meet the inclusion criteria * For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator * Any adverse or serious adverse events during the study period judged by investigator
Where this trial is running
Hangzhou, Zhejiang
- Second Affilated Hospital of Zhejiang University, School of Medicine — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Min Lou, PhD, MD
- Email: lm99@zju.edu.cn
- Phone: 13958007213
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.