Registration of patients with narrowing of brain or neck arteries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect and analyze data from patients aged 40 and older who have significant narrowing (≥ 50%) in their intracranial or carotid arteries. Participants will undergo standard medical treatment and may receive interventional stenting, while their clinical information, neuropsychological assessments, and multimodal MRI results will be documented. The goal is to identify cognitive impairments associated with these conditions early on, enhancing understanding and management of cognitive function in affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged ≥ 40 years
* ≥ 50% stenosis in unilateral intracranial / carotid artery
* Written informed consent available

Exclusion Criteria:

* Previous history of major head trauma and any intracranial surgery
* Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions
* Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement
* Severe loss of vision, hearing, or communicative ability

Exit Criteria:

* Not meet the inclusion criteria
* For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator
* Any adverse or serious adverse events during the study period judged by investigator

Where it's running

• Second Affilated Hospital of Zhejiang University, School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Min Lou, PhD, MD
• Email: lm99@zju.edu.cn
• Phone: 13958007213

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.