Understanding COVID-19's Effects on Brain Health in Aging and Alzheimer's Disease
Acute and Long-Term Impact of SARS-CoV-2 Infection and its Interaction with APOE on Cognitive Function and Neuropathology in Aging and Alzheimer's Disease
This project looks at how COVID-19 affects thinking and brain health over time, especially in older adults and those with a gene linked to Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11297471 on NIH RePORTER |
What this research studies
We know that COVID-19 can cause brain damage and lasting neurological problems for many survivors. This project explores how the virus impacts brain function and changes in the brain, particularly in older individuals. We are also interested in how a specific gene, APOE4, which increases the risk for Alzheimer's disease, might influence how severe COVID-19's effects are on the brain. Our goal is to uncover the underlying reasons why some people experience more severe brain-related issues after a SARS-CoV-2 infection.
Who could benefit from this research
Good fit: Ideal candidates for future related efforts might include older adults, individuals with a history of COVID-19, or those with a genetic predisposition like the APOE4 gene, particularly if they are experiencing cognitive changes.
Not a fit: Patients who have not had COVID-19 or who are not concerned about long-term cognitive effects related to aging or Alzheimer's disease may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: This work could help us better understand and potentially prevent or treat the long-term brain and memory problems that can follow a COVID-19 infection, especially for those at higher risk for Alzheimer's disease.
How similar studies have performed: While the acute neurological effects of COVID-19 are recognized, this project delves into the specific long-term interactions with aging and genetic factors like APOE, which is a less understood area.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Li, Ling — University of Minnesota
- Study coordinator: Li, Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.