Genetics and Cognitive Function in Mexican Teachers Cohort for Alzheimer’s Dementia
Official title: Mexican Teachers Cohort Study: Genetics and Cognitive Function
Funded at Rush University Medical Center · NIH-11595536 · Data updated 2026-11-12
This grant funds a large study to find genetic factors linked to memory and thinking in Mexican teachers, with the goal of improving understanding of Alzheimer’s-related dementia.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $61,798 |
| NIH project number | 3U01AG084547-03S1 |
| Project ID | NIH-11595536 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults, particularly 65 and older, who are part of or connected to the Mexican Teachers Cohort and willing to contribute genetic data.
✕Less likely to help
Individuals not connected to the Mexican Teachers Cohort or without interest in genetic research may not benefit.
What this research studies
If funded, researchers will combine genetic data from nearly 20,000 GWAS and 5,000 whole genomes from Mexican teachers with data from other groups to look for genetic drivers of cognitive function. The study focuses on aging adults, including those 65 and older, and aims to reveal how ancestry and genetics influence dementia risk in diverse populations. Results could help identify people at higher risk earlier and guide future dementia research and prevention efforts. Participants would come from the Mexican Teachers Cohort, a long-running group with high follow-up, to ensure robust findings. This work may pave the way for more inclusive genetic discoveries in ADRD across Hispanic populations.
Why it matters
Potential benefit: Could lead to better understanding of dementia risk in Hispanic populations and inform more personalized prevention and treatment approaches.
How similar studies have gone: Similar large-scale genetic studies of dementia have yielded meaningful insights, but expanding to diverse populations is still relatively novel and promising.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Grodstein, Francine — Rush University Medical Center
- Study coordinator: Grodstein, Francine
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Mexican Teachers Cohort Study: Genetics and Cognitive Function
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.