Canagliflozin to protect the aging brain and improve cognition in Alzheimer’s disease

Who could benefit from this research

What this research studies

This project explores whether an FDA-approved diabetes medication, canagliflozin, can slow aging-related brain changes and improve cognitive functions in older adults with Alzheimer’s-related conditions. Researchers are studying its effects on brain inflammation, insulin signaling in the brain, and behavior in aging models and human contexts, with a focus on translating promising findings toward people. The work includes collaboration with the Intervention Testing Program to examine neuroprotective properties and possible cognitive benefits in aging and Alzheimer’s disease. The goal is to identify whether Cana could become a safe, repurposed option to support brain health in patients as they age.

Why it matters

Where this research is happening

• Wayne State University
  Detroit, United States Active

Researchers

• Principal investigator: Sadagurski, Marianna — Wayne State University
• Study coordinator: Sadagurski, Marianna

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.