Genetics and memory in Mexican teachers
Mexican Teachers Cohort Study: Genetics and Cognitive Function
['FUNDING_U01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-11384674
This project looks at how genes relate to memory and thinking in older Mexican teachers by adding their genetic data to a large Alzheimer's research effort.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11384674 on ClinicalTrials.gov |
What this research studies
You would be part of a long-running group of Mexican teachers whose health and memory have been tracked over years. Researchers will collect DNA data using genome-wide arrays for about 20,000 people and whole-genome sequencing for about 5,000 people from this group and link those data with other Alzheimer's datasets. The team will combine genetic results with the cohort's cognitive records to find gene differences tied to memory and dementia risk. The work focuses on Mexican and Hispanic backgrounds that are underrepresented in Alzheimer genetics research.
Who could benefit from this research
Good fit: Ideal candidates are Mexican or Mexican-descent women from the Mexican Teachers Cohort, especially older adults who can provide health information and a DNA sample.
Not a fit: People without Mexican/Hispanic ancestry or those looking for immediate treatment changes are unlikely to receive direct clinical benefit from this genetics-focused study right away.
Why it matters
Potential benefit: If successful, this work could reveal genetic risk factors that improve diagnosis, risk prediction, and eventually guide treatments tailored for Mexican and Hispanic communities.
How similar studies have performed: Large Alzheimer genomics projects have already identified risk genes in other populations, and this project applies those successful genomic approaches to an understudied Mexican cohort.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRODSTEIN, FRANCINE — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: GRODSTEIN, FRANCINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.