How cigarette smoke affects cell responses through tRNA modifications
Official title: Translational regulation during cigarette smoking-induced reprogramming of the tRNA epitranscriptome, in vitro and in a mouse smoking model
Funded at State University of New York at Albany · NIH-10823293 · Data updated 2026-11-12
This study is looking at how cigarette smoke affects tiny molecules in our cells that help control how genes work, which could help us understand how smoking impacts our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 9, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $377,990 |
| NIH project number | 5R01ES031529-05 |
| Project ID | NIH-10823293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who smoke or have been exposed to environmental tobacco smoke and are at risk for related health issues.
✕Less likely to help
Patients who do not smoke and have no exposure to tobacco smoke or its byproducts may not benefit from this research.
What this research studies
This research investigates how exposure to cigarette smoke alters the tRNA epitranscriptome, which is crucial for regulating gene expression and cell survival. By using both in vitro methods and a mouse model, the study aims to uncover the mechanisms by which toxicants in cigarette smoke impact cellular responses. The researchers will analyze changes in modified ribonucleosides in tRNA and their effects on protein translation, particularly in stress-response genes. This work could provide insights into the cellular adaptations that occur in response to harmful substances found in tobacco smoke.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases caused by smoking, such as cardiovascular disease and lung cancer.
How similar studies have gone: Previous research has shown that understanding the epitranscriptome can reveal important insights into cellular responses to toxic exposures, suggesting that this approach has potential for success.
Where this research is happening
-
State University of New York at Albany
Albany, United States Active
Researchers
- Principal investigator: Begley, Thomas J — State University of New York at Albany
- Study coordinator: Begley, Thomas J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.