Condition

Cardiovascular Risk clinical trials and research

• 10Clinical trials
• 112NIH research projects
• 1New in 30 days
• 20Countries

Newest Cardiovascular Risk clinical trials

All recruiting trials (10)

• Kidney and Heart Health in Adults with Type 2 Diabetes and CKD Treated with Semaglutide in China

  This study tests whether semaglutide injections help kidney and heart health in adults with type 2 diabetes and chronic kidney disease.

  Recruiting Phase 4 Novo Nordisk A/S · Fuyang, Anhui and 25 other locations · NCT07900438

• Understanding why some people see bigger LDL drops after starting ezetimibe

  This study tests what factors predict how much a person’s LDL cholesterol drops after starting ezetimibe, to help tailor cholesterol treatment.

  Recruiting Phase 4 Universidade do Porto · Porto · NCT07839741

• Zenagamtide vs insulin glargine in type 2 diabetes with heart risk

  This trial tests whether weekly injections of zenagamtide can lower blood sugar and body weight better or differently than insulin glargine in people with type 2 diabetes and high cardiovascular risk who are on 1–3 other diabetes medicines.

  Recruiting at 56 sites Phase 3 Novo Nordisk A/S · Birmingham, Alabama and 329 other locations · NCT07797335

• Can mouth health and chewing help explain arterial stiffness in healthy adults

  This study tests whether a profile of oral health and function adds information about central arterial stiffness beyond traditional risk factors in healthy adults.

  Recruiting VASCage GmbH · Innsbruck, Tyrol · NCT07736222

• Corrie Lipids program to help lower high LDL cholesterol

  This program tests whether a smartphone app combined with clinician education and coaching can help adults with uncontrolled LDL-C and high cardiovascular risk reach their cholesterol goals.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07478887

• Diabetes Complications in People with Cystic Fibrosis-Related Diabetes (SPeCTRuM)

  This project will see how common diabetes-related complications (like eye, nerve, and blood vessel problems) are in adolescents and adults living with cystic fibrosis-related diabetes.

  Recruiting at 5 sites Jaeb Center for Health Research · Birmingham, Alabama and 17 other locations · NCT06837181

• Evaluating new methods for predicting cardiovascular disease risk in Italy

  This study is testing whether using genetic and imaging information can help people in Italy understand their risk of heart disease better and improve their health through tailored advice and treatment.

  Recruiting at 7 sites IRCCS Policlinico S. Donato · Ancona and 16 other locations · NCT06832644

• Monitoring blood pressure continuously to improve hypertension management

  This study is testing whether using a continuous blood pressure monitoring device can help people with high blood pressure manage their condition better over ten years.

  Recruiting at 2 sites Aktiia SA · Lausanne and 1 other locations · NCT06670677

• Exploring how different amounts of resistance exercise affect heart health

  This study is testing how different amounts of resistance exercise can improve heart health in people at risk for cardiovascular disease.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06619444

• Multidisciplinary care for cardiovascular risk in prostate cancer patients on hormone therapy

  This study is testing if a team-based approach to care can help men with prostate cancer on hormone therapy lower their heart health risks.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06163924

NIH-funded research (newest 40 of 112)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cardiovascular risk planning and reduction for men with prostate cancer

  A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11627340

• Traumatic Stress, Epigenetic Aging, and Heart Risk in Veterans

  A large study using Veterans Affairs data to see if traumatic stress and faster biological aging relate to higher risk of stroke and heart disease.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11531287

• Lifestyle plan to protect muscle and heart health for adults with obesity using GLP-1 medications

  A real-world trial tests a combined nutrition and resistance-training program versus standard care for adults starting GLP-1 weight loss drugs to preserve lean mass and cardiovascular health.

  NIH research University of Florida · Gainesville, United States · NIH-11452740

• Role of the body's natural cannabis-like system in diabetes progression and heart risk

  This grant studies how the body's endocannabinoid system affects the progression from obesity to diabetes and the associated risk for cardiovascular disease in adults.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11451041

• Community and Peer Support for Reducing Cardiovascular Risk

  Aims to understand how community and peer programs can help people lower cardiovascular risk, by analyzing existing programs and how their implementation and social support influence outcomes.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11445431

• CardioPredict ML: A smarter way to gauge heart risk before pregnancy

  A machine learning tool helps identify women at risk for pregnancy-related heart problems before conception, using health records and prior pregnancy data.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11445270

• Blood vessel signals predicting heart problems after kidney transplant

  This project studies blood markers and tissue patterns after kidney transplants to identify which patients are at highest risk of cardiovascular problems.

  NIH research Yale University · New Haven, United States · NIH-11441506

• A new tool to predict heart risk for people who use stimulants

  A new clinical tool will help doctors estimate a patient’s risk of heart problems more accurately for people who use cocaine or methamphetamines.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11437580

• History of high blood pressure during pregnancy and heart risk in menopause

  This research looks at whether women who had high blood pressure problems during pregnancy have higher heart disease risk during and after menopause.

  NIH research University of Washington · Seattle, United States · NIH-11431384

• Improving retention in hypertension care for people with HIV in safety net clinics

  A patient-focused study to help people with HIV in safety net clinics keep their blood pressure under control and reduce heart disease risk.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11421399

• Reducing heart disease risk in people with HIV by treating hidden CMV virus

  Treating hidden CMV replication in people living with HIV who are on ART may lower vascular inflammation and cardiovascular risk.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11420028

• Circadian rhythms and sleep for better blood sugar and heart health in adults with type 1 diabetes

  A study tests whether improving sleep duration and regularity can help adults with type 1 diabetes control blood sugar and lower heart-disease risk.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11418350

• Biomarkers for plant-rich diets and their links to heart health

  This grant tests whether biomarkers in urine and blood can show if a person is following a plant-rich diet and whether this relates to lower heart disease risk.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11417258

• Heart health and risk factors in Haiti

  Following adults in Haiti over time to understand what leads to heart disease and who is most at risk.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11414807

• Cardiovascular risk, circadian misalignment, and longer eating windows in short sleepers

  A study to understand how extending eating periods affects heart health in adults who sleep less than ideal hours.

  NIH research Lsu Pennington Biomedical Research Ctr · Baton Rouge, United States · NIH-11406201

• Cholesterol lowering and heart risk in adults with type 1 diabetes

  This project tests how heart-healthy cholesterol reduction affects blood vessels in adults with type 1 diabetes to help prevent heart disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11402612

• Improving Heart Health Prediction and Treatment in Sleep Apnea with Advanced AI

  A new NIH grant aims to use smart AI tools to better predict heart risk and tailor CPAP treatment for people with sleep apnea using data from sleep tests.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11384496

• From Food Insecurity to Cardiovascular Risk: A Biobehavioral Look at Nutrition and Inflammation

  This project follows 450 Hispanic/Latino adults over time to see how food insecurity affects heart health through nutrition and inflammation.

  NIH research Rice University · Houston, United States · NIH-11379915

• Epigenetic markers of heart disease risk in African American women

  A study exploring how epigenetic changes relate to heart disease risk in African American women to help improve prediction and prevention.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11378025

• Endogenous circadian clocks and cardiovascular risk rhythms

  A research team at a major university is studying how the body's internal clock affects heart and blood vessel health, especially in the morning when heart risks can spike.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11377031

• Lowering heart disease risk for adults facing food insecurity with structured incentives

  This project offers structured incentives and support to help adults who lack steady access to food lower their heart disease risk factors.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11375150

• How daily stress affects heart health in urban African American adults

  Researchers will follow middle-aged and older African American adults in urban areas to link daily stress, emotions, and behaviors with heart disease risk.

  NIH research Wayne State University · Detroit, United States · NIH-11373857

• Eicosanoids and kidney disease link to heart risks

  This grant explores how tiny fat-derived molecules (eicosanoids) influence kidney disease and heart risk in adults.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11367536

• Postmenopausal androgens and heart risk in aging women

  A funded project will study how hormones after menopause relate to heart disease risk in aging women.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11365488

• Integrative computational and lab approaches to better predict cardiovascular risk from genes and variants

  Aiming to combine big patient data with fast lab tests to understand how rare gene changes affect cholesterol and heart disease risk.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11365365

• A statewide community plan to improve heart health and cancer outcomes through better diet and activity

  A statewide program in Rhode Island tests a community approach to make healthier eating and more physical activity easier, with goals to improve heart health and cancer-related risk factors.

  NIH research Brown University · Providence, United States · NIH-11342062

• AI that uses social and health information to improve heart disease risk predictions

  This project creates AI tools that combine medical records and social factors to give fairer, more accurate heart disease risk predictions for people from racial, ethnic, and low-income backgrounds.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11323993

• Redefining heart risk in dialysis patients

  Aimed at better predicting heart risk in people with chronic kidney disease who are on dialysis, using new tests during exercise instead of only resting measurements.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11323932

• Blood-test guided heart protection after non-cardiac surgery

  This project compares blood test–guided long-term low-dose anticoagulant plus high-intensity statin therapy to usual care for people who have heart injury after non-cardiac surgery.

  NIH research New York University School of Medicine · New York, United States · NIH-11323508

• How aldosterone may raise blood pressure and heart risk during menopause

  This project will measure aldosterone and renin in women before, during, and after menopause to link hormone changes with rising blood pressure.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11323147

• How some HIV medicines might harm the heart

  Looking at whether certain HIV drugs cause heart scarring and raise the risk of sudden death for people living with HIV.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11310194

• Cardiovascular risk from a detailed CT calcium score analysis using AI

  A patient-friendly study using AI to analyze CT calcium scores and fat in the chest to better predict who might have a future heart event.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11309615

• Why heart disease is rising in rural women

  This project looks at how everyday stress, social factors, and biological changes may raise heart disease risk in adults living in rural Southern communities, with a focus on women aged 25–64.

  NIH research Emory University · Atlanta, United States · NIH-11309586

• Enhancing HIV-related heart disease risk tools with new data from the REPRIEVE trial

  This project uses the REPRIEVE trial data to build a more accurate heart disease risk score for people living with HIV by combining biomarkers, imaging, and genetics.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11303267

• Improving how doctors help patients stick to cholesterol-lowering medicines with smart checks in the electronic chart

  A hospital-based project is testing an easy-to-use electronic health record tool to help patients with ASCVD start and continue statin therapy.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11293674

• Long-term stress and heart health in frontline emergency workers after COVID-19

  This project looks at whether lasting anxiety, stress, and sleep problems in emergency department healthcare workers after COVID-19 affect their future heart health.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11290732

• Reducing leftover heart disease risk beyond standard cholesterol treatment

  This program is developing new ways to lower the leftover risk of heart attack and stroke in people who already have low LDL cholesterol.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11249194

• Heart, blood vessel, and kidney health after COVID-19

  This project follows people who had COVID-19 to learn how the infection may affect their heart, blood vessels, and kidneys over months to years.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11239778

• Intradialytic Heart Stress in Dialysis Patients

  A study in people on hemodialysis to understand why their heart sometimes gets stressed during treatment and how this might raise the risk of heart problems.

  NIH research New York University School of Medicine · New York, United States · NIH-11229583

• Understanding Heart Health in African American Women

  This project aims to understand how changes in our genes, influenced by lifestyle and environment, affect heart health in African American women.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11193943

Related topics

Quick answers

How many Cardiovascular Risk clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (4 trials), China (2 trials), United Kingdom (2 trials), Italy (2 trials), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →