Cholesterol lowering and heart risk in adults with type 1 diabetes
Official title: Cholesterol reduction and cardiovascular risk in Type 1 diabetes
Funded at New York University School of Medicine · NIH-11402612 · Data updated 2026-11-12
This project tests how heart-healthy cholesterol reduction affects blood vessels in adults with type 1 diabetes to help prevent heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $616,678 |
| NIH project number | 5R01HL164949-05 |
| Project ID | NIH-11402612 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 1 diabetes who are candidates for high-intensity cholesterol-lowering therapy and can undergo vascular imaging and blood sampling.
✕Less likely to help
Patients who cannot receive PCSK9 inhibitors or high-dose statins/ezetimibe or who cannot participate in vascular imaging may not benefit from the study.
What this research studies
People with type 1 diabetes often have higher risk of artery problems even when cholesterol is lowered. The study will enroll adults with T1D at NYU Langone Health and Mount Sinai, give strong cholesterol-lowering treatment with PCSK9 inhibitors plus either a statin or ezetimibe for four weeks, and examine how their arteries repair and respond by checking blood and vascular imaging. Researchers will look at white blood cells, endothelial cells, and other markers to identify pathways that influence vascular healing after cholesterol reduction. The goal is to find characteristics that predict poor response and to uncover potential targets to improve cardiovascular outcomes in this population.
Why it matters
Potential benefit: If successful, the findings could lead to more effective cholesterol-lowering strategies and new targets to reduce heart attack and stroke risk in people with type 1 diabetes.
How similar studies have gone: Prior work suggests LDL-C reduction can influence vascular repair, but this study directly explores response patterns in type 1 diabetes with combination therapies.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Goldberg, Ira J — New York University School of Medicine
- Study coordinator: Goldberg, Ira J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.