Blood-test guided heart protection after non-cardiac surgery
Post-Operative Biomarker-Guided Precision Medicine for Cardiovascular Risk Reduction
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11323508
This project compares blood test–guided long-term low-dose anticoagulant plus high-intensity statin therapy to usual care for people who have heart injury after non-cardiac surgery.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11323508 on ClinicalTrials.gov |
What this research studies
If you have non-cardiac surgery, doctors will check your blood for troponin to see if you had a heart injury (MINS). If troponin is elevated, this pilot will randomly assign eligible patients to a plan that adds a low-dose direct oral anticoagulant and a high-strength statin for the long term or to usual care. The team will test whether this biomarker-guided approach is practical at busy surgical hospitals, refine who should join and exactly how treatments are given, and measure how well patients stick with the plan. Results will be used to plan a larger international trial if the pilot shows the approach is feasible.
Who could benefit from this research
Good fit: People who develop elevated post-operative troponin (myocardial injury after non-cardiac surgery) and who can safely take anticoagulant and statin medications are the intended candidates.
Not a fit: Patients without postoperative troponin elevation, those who had cardiac surgery, or those who cannot take anticoagulants or high-intensity statins are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, this approach could lower future heart attacks and deaths after surgery by targeting preventive medicines to people with post-operative heart injury.
How similar studies have performed: Prior research shows MINS is linked to worse outcomes, but using postoperative troponin to guide long-term anticoagulant plus high-intensity statin therapy is a novel approach that has not yet been proven in large trials.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMILOWITZ, NATHANIEL ROSSO — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: SMILOWITZ, NATHANIEL ROSSO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease