Eicosanoids and kidney disease link to heart risks
Official title: Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk
Funded at Cedars-Sinai Medical Center · NIH-11367536 · Data updated 2026-11-12
This grant explores how tiny fat-derived molecules (eicosanoids) influence kidney disease and heart risk in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,784,866 |
| NIH project number | 4R01DK141162-03 |
| Project ID | NIH-11367536 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic kidney disease or at risk for CKD who may have inflammation-related heart risk.
✕Less likely to help
If your CKD is not linked to inflammatory pathways, results may be less directly applicable to you.
What this research studies
If you have CKD or are at risk, this research aims to map how inflammatory fats affect kidney function and heart health. Scientists will use advanced mass spectrometry to profile many eicosanoids in people and relate them to kidney and cardiovascular outcomes. The study focuses on understanding why some people progress faster and develop heart complications, guiding future treatments. The project is led by Cedars-Sinai in Los Angeles and spans several years to build a clearer picture of these connections.
Why it matters
Potential benefit: A clearer understanding of the inflammatory signals linking CKD to heart disease could lead to targeted therapies in the future.
How similar studies have gone: Other studies have shown links between inflammatory lipid pathways and kidney/heart outcomes, but this project aims for a deeper, broader mapping.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Cheng, Susan — Cedars-Sinai Medical Center
- Study coordinator: Cheng, Susan
Related research
Other NIH-funded projects on the same topics.
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Eicosanoids and Heart Risk in Chronic Kidney Disease
This research explores how natural body chemicals called eicosanoids might connect chronic kidney disease with heart problems.
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Investigating how eicosanoids affect kidney disease and heart health
This study is looking at how certain tiny molecules from fats affect kidney disease and heart health in people with chronic kidney disease, hoping to find new ways to help manage these conditions better.
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Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
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Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.