Intradialytic Heart Stress in Dialysis Patients
Official title: Intradialytic Myocardial Stunning in Hemodialysis Patients - a Novel Cardiovascular Risk Factor
Funded at New York University School of Medicine · NIH-11229583 · Data updated 2026-11-12
A study in people on hemodialysis to understand why their heart sometimes gets stressed during treatment and how this might raise the risk of heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 24, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2026 |
| Award (this year) | $670,338 |
| NIH project number | 5R01HL157220-05 |
| Project ID | NIH-11229583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with kidney failure undergoing regular hemodialysis who may be at risk for cardiovascular complications.
✕Less likely to help
Patients without access to regular dialysis or with conditions that are not related to heart health during dialysis may not benefit.
What this research studies
This project looks at how heart muscle stress happens during dialysis (intradialytic myocardial stunning) and how it might contribute to heart failure and dangerous rhythms. Researchers will examine patient data and biological markers to identify who is most at risk and what mechanisms drive these changes. The goal is to find targets for preventing heart damage during dialysis and reducing cardiovascular deaths in this high-risk population.
Why it matters
Potential benefit: If successful, findings could lead to new approaches to protect the heart during dialysis and reduce sudden cardiac deaths.
How similar studies have gone: Previous studies suggest intradialytic heart stress is linked to worse outcomes, but results are inconsistent and more research is needed to confirm mechanisms and risk factors.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Charytan, David M — New York University School of Medicine
- Study coordinator: Charytan, David M
Related research
Other NIH-funded projects on the same topics.
-
Investigating heart issues during dialysis in patients
This study is looking into a heart issue called intradialytic myocardial stunning that affects people on hemodialysis, with the goal of finding out how it leads to heart problems and discovering new ways to help improve their health.
-
Examining how cardiovascular risk factors change throughout adulthood and their link to disease.
This study looks at how things like blood pressure and cholesterol change from young adulthood to older age and how these changes can affect heart health, helping people understand their risks and improve prevention strategies for heart disease.
-
Understanding heart disease risk in patients on hemodialysis
This study is looking at why people with severe kidney disease who are on dialysis often have heart problems, and it will check blood samples to find out which proteins might be linked to heart health, with the goal of creating better ways to prevent and treat heart disease for these patients.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Traumatic Stress, Epigenetic Aging, and Heart Risk in Veterans
A large study using Veterans Affairs data to see if traumatic stress and faster biological aging relate to higher risk of stroke and heart disease.
-
Lifestyle plan to protect muscle and heart health for adults with obesity using GLP-1 medications
A real-world trial tests a combined nutrition and resistance-training program versus standard care for adults starting GLP-1 weight loss drugs to preserve lean mass and cardiovascular health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.