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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Corrie Lipids program to help lower high LDL cholesterol

Official title: Corrie Lipids Program: Optimizing LDL-Cholesterol by Improving Awareness, Access, and Achievement

Run by Johns Hopkins University · NCT07478887 · Data updated 2026-11-12

This program tests whether a smartphone app combined with clinician education and coaching can help adults with uncontrolled LDL-C and high cardiovascular risk reach their cholesterol goals.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1000 (estimated)
SponsorJohns Hopkins University
Academic / other
Locations1 site (Baltimore, Maryland)
StatusRecruiting
StartedJune 20, 2025
Main results expectedJune 2027
Study endsDecember 2027
Registry record updatedMarch 18, 2026
Trial IDNCT07478887 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older with uncontrolled LDL-C per AHA/ACC guidelines, elevated ASCVD risk or related conditions, access to a smartphone, and a prescribing primary care clinician or cardiologist are ideal candidates.

Probably not a fit

Patients without a smartphone, who do not speak English, or who have motor, cognitive, auditory, or visual impairments that prevent technology use (as well as pregnant individuals or those with excluded active malignancies) are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study will implement the Corrie Lipids digital health program across multiple clinical sites and follow about 1,000 adults with uncontrolled LDL-C and elevated ASCVD risk. The intervention pairs a patient-facing smartphone app with clinician education, coaching, and integration into clinical workflows. Investigators will measure LDL-C goal attainment, app engagement, prescribing patterns, and LDL-C monitoring using the RE-AIM implementation framework. The study will also identify barriers and facilitators to adoption at participating sites.

Why it matters

Potential benefit: If successful, the program could help more high-risk patients reach LDL-C targets faster by combining app-driven support with clinician workflow changes.

How similar studies have gone: Smaller digital health and clinician-coaching programs have shown promise for improving adherence and lipid outcomes, but large multicenter implementation data remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age ≥18 years
* Uncontrolled LDL-C per AHA/ACC guidelines
* At least 1 major cardiovascular risk factor, including: high risk for ASCVD (individuals who meet criteria for Lipid-Lowering Therapy (LLT) based on ASCVD risk assessment using the most up-to-date guidelines), known ASCVD or subclinical ASCVD based on imaging, clinically diagnosed familial hypercholesterolemia or LDL-C ≥190 mg/dL, diabetes mellitus, history of statin-associated side effects
* Has a primary care physician and/or cardiologist who can prescribe lipid therapy
* Owns a smartphone and agrees to the End User License Agreement to use the digital health app
* Provided informed consent before initiation of study-specific activities

Exclusion Criteria:

* Motor, cognitive, auditory, or visual impairment limiting technology use
* Does not speak English
* Malignancy (except nonmelanoma skin cancers or cervical or breast ductal carcinoma in situ within the previous 5 years)
* Pregnancy (positive pregnancy test, highly sensitive urine or serum), plan to become pregnant or donate eggs, breastfeeding or plan to breastfeed
* Likely to not be available to comply with all required study procedures to the best of the patient's and investigator's knowledge
* History or evidence of any other clinically significant disorder, condition, or disease that, in the opinion of the investigator, would pose a risk to patient safety or interfere with the study evaluation, procedures, or completion

Where it's running

  • Johns Hopkins University School of Medicine
    Baltimore, Maryland, United States     Recruiting

Study contacts

  • Principal investigator: Stacey Schott, MD, MPH — Johns Hopkins University
  • Study coordinator: Francoise Marvel, MD
  • Email: fmarvel1@jhmi.edu
  • Phone: 410-502-0469

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Cardiovascular Risk 122LDL-C 2Digital Health 122Implementation Science 210Johns Hopkins University 3238
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.