Condition

Cystic Fibrosis (CF) clinical trials and research

• 36Clinical trials
• 3New in 30 days
• 13Countries

Newest Cystic Fibrosis (CF) clinical trials

All recruiting trials (36)

• Oropharyngeal suction and physiotherapy to detect lung bacteria in kids with chronic lung disease

  A randomized study will test whether taking samples from the throat with suction, with or without prior physiotherapy, can reliably detect bacteria in children 5–18 with chronic lung disease, compared with standard sample methods.

  Recruiting Corporacion Parc Tauli · Sabadell, Barcelona · NCT07903792

• Seeing if CFTR functioncan be restored in CF through patient cells with rare mutations

  This study tests whether testing a patient’s own nasal cells in the lab can predict if CFTR-modulator therapies might help people with uncommon CF mutations.

  Recruiting at 3 sites Istituto Giannina Gaslini · Catania and 2 other locations · NCT07889973

• Perceptions and Intentions Around a Change in CF Treatment

  This study asks adults with cystic fibrosis currently on ETI whether they would switch to VTD if their doctor offered it and what factors influence that decision.

  Recruiting at 6 sites Fondation Ildys · Caen and 11 other locations · NCT07885410

• How the CF medicines elexacaftor, tezacaftor, and ivacaftor behave in the body

  This study tests how the CF medicines elexacaftor, tezacaftor, and ivacaftor move through the body in patients with cystic fibrosis who are already taking the combination therapy.

  Recruiting Phase 4 Istituto Giannina Gaslini · Genova · NCT07809867

• Autogenic Drainage vs. Mechanical Chest Percussion in Children with Cystic Fibrosis

  In children aged 6-12 with cystic fibrosis, this study tests whether autogenic drainage helps lung function and comfort more than mechanical percussion.

  Recruiting Riphah International University · Multan Khurd, Punjab Province · NCT07729787

• Pharmacokinetics of Antibiotics in CF Patients on ETI

  This study tests how antibiotics behave in the body of people with cystic fibrosis who are taking the ETI modulator therapy and are being treated for a pulmonary infection.

  Recruiting Fondation Ildys · Roscoff · NCT07629986

• Proof of principle for linaclotide to improve gut symptoms in cystic fibrosis

  This will test whether linaclotide can increase intestinal fluid and ease constipation and abdominal symptoms in adults with cystic fibrosis.

  Recruiting Early Phase 1 University of Nottingham · Nottingham · NCT07569419

• New lipase NHS7108 safety and potential efficacy in adults with exocrine pancreatic insufficiency

  A 2-period study tests whether the new lipase NHS7108 works safely for adults with EPI by comparing it to the standard pancrelipase (Zenpep) at several doses over 14 days each.

  Recruiting at 7 sites Phase 2 Société des Produits Nestlé (SPN) · Scottsdale, Arizona and 38 other locations · NCT07559175

• Upper- and lower-limb exercise program for children with cystic fibrosis

  This program will test whether supervised upper- and lower-limb cycling and resistance exercises improve muscle strength, aerobic capacity, and lung function in children aged 6–18 with cystic fibrosis.

  Recruiting Riphah International University · Lahore · NCT07508904

• Inflammation, infection and treatments during severe cystic fibrosis flare-ups

  Researchers will follow people with cystic fibrosis who are at risk of severe lung flare-ups to see if symptoms, lung tests, and biological samples explain different responses to intravenous antibiotics.

  Recruiting University of Manchester · Cardiff and 5 other locations · NCT07484607

• ANG003 for pancreatic enzyme replacement in cystic fibrosis–related exocrine pancreatic insufficiency

  This trial will test whether ANG003, a new pancreatic enzyme replacement, works as well as Creon for people with cystic fibrosis who have exocrine pancreatic insufficiency.

  Recruiting at 21 sites Phase 2 Anagram Therapeutics, Inc. · Long Beach, California and 27 other locations · NCT07450547

• Self-help ACT toolkit for adults with cystic fibrosis

  This test tries a smartphone self-help version of Acceptance and Commitment Therapy (ACT) to reduce anxiety and depression and improve psychological flexibility for adults living with cystic fibrosis.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07436351

• Household water and home environments as sources of non-tuberculous mycobacteria in people with cystic fibrosis

  This study will test whether household water, dust, and soil carry non-tuberculous mycobacteria that could infect people with cystic fibrosis.

  Recruiting Research Center Borstel · Borstel, Schleswig-Holstein and 1 other locations · NCT07369414

• Effects of elexacaftor-tezacaftor-ivacaftor on metabolism, epigenetics, and gut bacteria in people with cystic fibrosis

  This project will test whether starting elexacaftor-tezacaftor-ivacaftor (ETI) changes blood metabolism, epigenetic markers, and the gut microbiome in people with cystic fibrosis.

  Recruiting Meyer Children's Hospital IRCCS · Bari, Bari and 5 other locations · NCT07363304

• Exercise-related breathing limits in adults with cystic fibrosis taking Elexacaftor‑Tezacaftor‑Ivacaftor

  We will test how often adults with cystic fibrosis who are taking Elexacaftor‑Tezacaftor‑Ivacaftor reach ventilatory limits during a six‑minute walk.

  Recruiting University Hospital, Lille · Lille · NCT07314229

• New ways to detect lung infections in people with cystic fibrosis

  This study is testing new methods to find harmful lung bacteria in people with CF who can still produce sputum, especially those on modern CF therapies.

  Recruiting at 6 sites Seattle Children's Hospital · La Jolla, California and 8 other locations · NCT07312734

• How Trikafta (elexacaftor‑tezacaftor‑ivacaftor) is handled by children’s bodies with cystic fibrosis

  This project will test how Trikafta (elexacaftor‑tezacaftor‑ivacaftor) is absorbed, distributed, metabolized, and eliminated in children aged 2–17 with cystic fibrosis.

  Recruiting Hospices Civils de Lyon · Bron · NCT07303621

• Wearable sensors and AI to detect chest infection flare-ups in adults with cystic fibrosis or bronchiectasis

  This study will try wearable sensors and AI to see if changes in breathing or heart rate can spot chest infection flare-ups early in adults with cystic fibrosis or bronchiectasis who are starting IV antibiotics.

  Recruiting Papworth Hospital NHS Foundation Trust · Cambridge, Cambridgeshire · NCT07289100

• AchromoPhage for adults with cystic fibrosis and chronic Achromobacter lung infection

  A small study tests a four-phage mix called AchromoPhage in adults with CF and long‑standing Achromobacter lung infection to see if it is safe and tolerable when given in different ways.

  Recruiting Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07275905

• Gut response to a Mediterranean diet in children with cystic fibrosis

  This project will try a Mediterranean-style diet in children with cystic fibrosis to see if it lowers gut inflammation, shifts the gut microbiome toward healthier bacteria, and supports better nutrition.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire and 1 other locations · NCT07223255

• Magnetic resonance lung imaging using hyperpolarised gas for cystic fibrosis

  This project tests advanced lung imaging with hyperpolarised xenon MRI together with multiple breath washout in people with cystic fibrosis to see if they reveal lung changes over time.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield · NCT07192679

• Ensuring access to optimal therapy for children with cystic fibrosis

  This project will test whether genetic testing and therapeutic drug monitoring can predict which children with cystic fibrosis will respond to the triple-combination elexacaftor/tezacaftor/ivacaftor therapy.

  Recruiting at 3 sites Phase 4 Arkansas Children's Hospital Research Institute · Birmingham, Alabama and 2 other locations · NCT07148739

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

• Cystic Fibrosis Wellness Program for Adults with Fatigue

  This pilot randomized trial will try a combined cognitive behavioral therapy and physical activity coaching program to see if it helps adults with cystic fibrosis who have significant fatigue sleep better, move more, and sit less.

  Recruiting Johns Hopkins University · Denver, Colorado and 2 other locations · NCT07071324

• Depression, anxiety, and behavior over time in children under 12 with cystic fibrosis

  This project will track how common depression, anxiety, and behavior problems are and how they change over time in children aged 18 months to 11 years who have cystic fibrosis.

  Recruiting at 12 sites State University of New York at Buffalo · Orange, California and 12 other locations · NCT07048574

• Nebulized phage (BX004) treatment for adults with CF and chronic Pseudomonas lung infection

  This trial will test whether inhaled phage therapy (BX004), given twice daily for 8 weeks, can reduce Pseudomonas aeruginosa in the sputum of adults with cystic fibrosis and chronic lung infection.

  Recruiting at 9 sites Phase 2 BiomX, Inc. · Birmingham, Alabama and 13 other locations · NCT06998043

• Stopping or continuing nasal rinses and topical nasal medicines for adults with cystic fibrosis on modulator therapy

  This project will see if adults with cystic fibrosis who are taking highly effective modulator therapy can safely stop nasal rinses and topical nasal steroid or antibiotic treatments without making sinus inflammation worse.

  Recruiting Phase 3 Indiana University · Indianapolis, Indiana · NCT06996951

• Evaluating lung function in severe asthma patients with mucus plugs

  This study is testing how mucus plugs in the lungs affect breathing and airflow in people with severe asthma using special imaging techniques.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06985225

• Physical function and symptoms in children with cystic fibrosis

  This project will compare breathing difficulty, exercise capacity, muscle strength, bladder control, and quality of life in children aged 6–18 with cystic fibrosis versus healthy peers to see where support is needed.

  Recruiting Izmir Democracy University · Izmir · NCT06984679

• Causes and risk factors of lung exacerbations in cystic fibrosis

  This project will test whether regular home and clinic sampling can identify causes and triggers of lung exacerbations in people with cystic fibrosis.

  Recruiting at 8 sites University of Manchester · Manchester, Manchester and 17 other locations · NCT06940531

• Improving lung function in children with cystic fibrosis

  This study is testing a new plan to help improve lung function in children with cystic fibrosis by seeing if personalized treatment can increase their breathing ability over a year.

  Recruiting Ain Shams University · Cairo, Abbasia · NCT06915961

• Diabetes Complications in People with Cystic Fibrosis-Related Diabetes (SPeCTRuM)

  This project will see how common diabetes-related complications (like eye, nerve, and blood vessel problems) are in adolescents and adults living with cystic fibrosis-related diabetes.

  Recruiting at 5 sites Jaeb Center for Health Research · Birmingham, Alabama and 17 other locations · NCT06837181

• Health of women with cystic fibrosis during pregnancy and their young children

  This project will follow women with cystic fibrosis who are planning pregnancy, pregnant, or new parents, and their babies to see how pregnancy and current CF treatments affect maternal physical and mental health and early child health.

  Recruiting Royal Brompton & Harefield NHS Foundation Trust · London · NCT06797206

• Understanding kidney disease in people with cystic fibrosis

  This study looks at how cystic fibrosis affects kidney health by checking blood and urine samples to help find ways to spot and prevent kidney problems early.

  Recruiting at 3 sites University of Virginia · Birmingham, Alabama and 2 other locations · NCT06595420

• Monitoring kidney function in cystic fibrosis patients during a treatment pause

  This study is testing how a short break from a specific cystic fibrosis treatment affects kidney function in adults with the condition.

  Recruiting University of Aarhus · Aarhus C, Central Jutland · NCT05818319

• Investigating how lung diseases affect white blood cells in the lungs

  This study is trying to see how Alpha-1-antitrypsin deficiency and Cystic Fibrosis affect important white blood cells in the lungs, which could help us understand lung inflammation and disease better.

  Recruiting University of Florida · Gainesville, Florida · NCT01851642

Related topics

Quick answers

How many Cystic Fibrosis (CF) clinical trials are recruiting right now?

36, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (16 trials), United Kingdom (7 trials), Italy (4 trials), France (4 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 4: 2, Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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