Redefining heart risk in dialysis patients
Official title: Redefining cardiovascular risk assessment in dialysis patients (ROCK-D) study
Funded at Indiana University Indianapolis · NIH-11323932 · Data updated 2026-11-12
Aimed at better predicting heart risk in people with chronic kidney disease who are on dialysis, using new tests during exercise instead of only resting measurements.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $706,312 |
| NIH project number | 5R01HL166747-04 |
| Project ID | NIH-11323932 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic kidney disease receiving dialysis who are at risk for cardiovascular events and able to undergo CPET and related imaging.
✕Less likely to help
Patients who cannot perform cardiopulmonary exercise testing or undergo certain imaging procedures may not benefit.
What this research studies
This project seeks to improve how doctors predict cardiovascular problems in patients with CKD on dialysis by combining innovative exercise-based assessments with heart imaging markers. It focuses on proving whether measurements like peak oxygen uptake during CPET can better forecast future heart events than traditional models. The study will enroll CKD patients to collect data on how their hearts respond to exercise and how imaging and other tests relate to risk. Findings could change how clinicians stratify risk and tailor prevention in this high-risk group.
Why it matters
Potential benefit: If successful, patients could receive more accurate heart risk assessments and personalized prevention strategies while on dialysis.
How similar studies have gone: Prior work suggests exercise-based and imaging approaches may improve risk prediction, but CKD-specific validation remains needed.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Lim, Kenneth — Indiana University Indianapolis
- Study coordinator: Lim, Kenneth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.