Blood vessel signals predicting heart problems after kidney transplant
Official title: Vascular Biomarkers and Tissue Signatures of Cardiovascular Risk in Kidney Transplant Recipients
Funded at Yale University · NIH-11441506 · Data updated 2026-11-12
This project studies blood markers and tissue patterns after kidney transplants to identify which patients are at highest risk of cardiovascular problems.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $126,000 |
| NIH project number | 1R03DK149525-01 |
| Project ID | NIH-11441506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Kidney transplant recipients monitored over time who have or are at risk for cardiovascular events.
✕Less likely to help
Patients not experiencing cardiovascular events or not contributing tissue/longitudinal samples may see limited direct benefit.
What this research studies
Kidney transplant recipients face a high risk of heart and blood vessel problems. The study will track specific blood vessel-related biomarkers over time after transplant and compare those with patients who do and do not experience cardiovascular events. Researchers will use detailed statistical methods to create a score from these biomarker trajectories to predict risk. The goal is to improve early identification and potentially tailor care for patients at higher risk. The work is done with data from Yale University and focuses on people who have received kidney transplants.
Why it matters
Potential benefit: If successful, clinicians could better predict and prevent cardiovascular events in kidney transplant patients.
How similar studies have gone: Previous studies show biomarker trajectories can help predict cardiovascular risk, but this project aims to enhance prediction specifically in kidney transplant patients.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Mansour, Sherry George — Yale University
- Study coordinator: Mansour, Sherry George
Related research
Other NIH-funded projects on the same topics.
-
Microbial clues to diagnose and predict infections in kidney transplant patients
A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.
-
Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
-
Complement-Bound Exosomes and Kidney Transplant Immunity
This project studies how kidney transplant injury and rejection happen after surgery and whether blocking certain immune pathways during organ preservation could improve transplant outcomes.
-
Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
-
Characterization of a LILRB3 SNP cluster and its link to kidney transplant outcomes
A study in kidney transplant recipients looks at genetic factors that may be tied to higher risk of graft failure.
-
Optimizing a prehabilitation program for kidney transplant candidates on dialysis
A program to improve physical function and readiness for kidney transplant in people on dialysis is being developed and tested to help candidates stay healthier while they wait.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.