Condition

Neuropathy clinical trials and research

• 25Clinical trials
• 135NIH research projects
• 9Countries

Newest Neuropathy clinical trials

All recruiting trials (25)

• Collecting clinical, nerve conduction, electromyography, and ultrasound data in adults with peripheral neuropathy

  This project will see if collecting detailed clinical, nerve conduction, electromyography, and ultrasound data from adults with peripheral neuropathy during routine visits can improve understanding and care.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07437989

• Blood microRNA markers for chemotherapy-related peripheral nerve damage in lung and colorectal cancer

  This study will test whether levels of tiny blood molecules called microRNAs can predict how often and how badly patients with lung or colorectal cancer get nerve damage from certain chemotherapies.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07427537

• Nerve effects of enfortumab vedotin in people with urothelial cancer

  We will see how nerve testing and patient-reported symptoms change in adults with urothelial cancer who are starting enfortumab vedotin.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07390617

• Transcutaneous pulsed radiofrequency for postherpetic neuralgia pain

  This study will try a non-invasive pulsed radiofrequency treatment applied through the skin to reduce pain in adults with postherpetic neuralgia who have not responded to standard treatments.

  Recruiting Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Istanbul, Istanbul · NCT07390279

• Feasibility of paired non-invasive blood flow and tissue oxygen monitoring to detect limb ischemia during lithotomy-position surgeries

  This study tests whether using combined non-invasive blood flow monitoring and tissue oxygen sensors during long lithotomy surgeries can help detect early limb ischemia in adults.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas and 1 other locations · NCT07387653

• Nerve excitability testing for cisplatin-related peripheral neuropathy

  This study will see if specialized nerve excitability tests (TTNCS) can detect early nerve changes in adults starting cisplatin or who recently finished cisplatin and have peripheral neuropathy.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts and 1 other locations · NCT07095998

• Home-use Erchonia EVRL laser for temporary relief of idiopathic peripheral neuropathy foot pain

  This study will test whether a home-use Erchonia EVRL laser can provide temporary relief of foot pain for adults with idiopathic peripheral neuropathy.

  Recruiting Erchonia Corporation · Miramar, Florida · NCT06912646

• Home-use Erchonia EVRL laser for temporary relief of idiopathic peripheral neuropathy foot pain

  This study will test whether a home-use Erchonia EVRL laser can provide temporary relief of foot pain for adults with idiopathic peripheral neuropathy.

  Recruiting Erchonia Corporation · Miramar, Florida · NCT06912646

• Diabetes Complications in People with Cystic Fibrosis-Related Diabetes (SPeCTRuM)

  This project will see how common diabetes-related complications (like eye, nerve, and blood vessel problems) are in adolescents and adults living with cystic fibrosis-related diabetes.

  Recruiting at 5 sites Jaeb Center for Health Research · Birmingham, Alabama and 17 other locations · NCT06837181

• Evaluating urinary dysfunction in patients with CANVAS

  This study is trying to see how common urinary problems are in people with CANVAS and if these issues are linked to their neurological symptoms.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes Maritimes and 2 other locations · NCT06817707

• Investigating pain mechanisms in patients with spinal cord injuries

  This study is trying to understand how spinal cord injuries cause nerve pain by looking at how the body processes pain and responds to it in people with different types of spinal injuries and nerve issues.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT06443281

• Using neuromodulation to treat pain from chemotherapy-induced peripheral neuropathy

  This study is testing a new way to relieve pain from nerve damage caused by chemotherapy in patients with lower extremity CIPN.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06121232

• Electrical stimulation to improve recovery after cubital tunnel surgery

  This study is testing a new electrical stimulation treatment to see if it helps people recover better after surgery for cubital tunnel syndrome.

  Recruiting at 2 sites Epineuron Technologies Inc. · Hamilton, Ontario and 1 other locations · NCT05980767

• Evaluating Ketotifen's protective role against chemotherapy-induced nerve damage

  This study is testing if Ketotifen can help prevent nerve damage caused by chemotherapy in people with stage III colorectal cancer.

  Recruiting Phase 3 Tanta University · Tanta, Other · NCT05624138

• Using multi-sensory stimulation to help patients with neuropathy and chronic pain

  This study is testing whether a combination of virtual reality and electrical nerve stimulation can help people with neuropathy and chronic pain feel better.

  Recruiting ETH Zurich · Zurich, Canton of Zurich · NCT05483816

• Collecting data on patients with neuromuscular disorders

  This study is collecting information from people with neuromuscular disorders who aren't part of other research to help improve understanding of these conditions and support future studies.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05041387

• Peripheral nerve block for painful diabetic neuropathy

  This study is testing if a nerve block can help adults with painful diabetic neuropathy feel less pain without stopping their regular medications.

  Recruiting University of Aarhus · Aarhus N, Jutland · NCT04699734

• Assessing the effects of spinal cord stimulators on diabetic neuropathy

  This study is testing if spinal cord stimulators can help people with diabetes and painful nerve damage feel better and improve their overall health.

  Recruiting University of Chicago · Chicago, Illinois · NCT04687215

• Using IVIG to treat gastrointestinal autoimmune neuropathy

  This study is testing whether intravenous immunoglobulin (IVIG) can help people with autoimmune gastrointestinal issues feel better when other treatments haven't worked.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04208828

• Daily hand-held vibration therapy for neuropathy relief

  This study is testing if a daily 3-minute hand-held vibration therapy can help people with chemotherapy-induced nerve pain in their hands feel better and improve their quality of life.

  Recruiting at 3 sites Indiana University · Avon, Indiana and 2 other locations · NCT04207437

• Rehabilitation for balance issues in patients with neuropathy

  This study tests whether different types of balance rehabilitation can help people with neuropathy improve their balance and walking stability.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT03881930

• Collecting data on pupillometer assessments in neuro-intensive care

  This study is gathering information on how pupils react in critically ill patients to help doctors better understand and interpret these assessments in intensive care.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT02804438

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

• Identifying genetic variants linked to nerve damage in breast cancer patients treated with paclitaxel

  This study is trying to find out if certain genetic factors make breast cancer patients more likely to experience nerve damage after receiving the chemotherapy drug paclitaxel.

  Recruiting National Cancer Institute (NCI) · Boston, Massachusetts · NCT02610439

• MRI-guided cryoablation for pain relief in the head, neck, and spine

  This study is testing a new way to relieve pain in the head, neck, and spine by using a special technique that freezes pain-causing nerves to see if it works better than regular treatments for people with joint or nerve issues.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT01788410

NIH-funded research (newest 40 of 135)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients

  This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).

  NIH research University of Arizona · Tucson, United States · NIH-11473607

• Neonatal Fc receptor blockade by efgartigimod to help inflammatory nerve disease

  Aims to test how blocking a specific antibody trafficking receptor with efgartigimod could improve nerve inflammation in a model of AIDP/GBS-type neuropathy.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11453598

• Schwann cell aging and secretions linked to diabetic nerve damage

  A research project looking at how aging nerve cells and their secretions may drive nerve damage in people with type 2 diabetes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11447445

• Diabetic bladder problems in diabetes mice show sex-specific nerve and inflammation roles

  Aims to understand why bladder problems happen in diabetes, exploring how inflammation and nerves differ between male and female mice.

  NIH research Duke University · Durham, United States · NIH-11446046

• Prenyltransferase inhibitor as a new therapy for inflammatory neuropathy

  A new drug candidate called FGTI-2734 is being studied to calm nerve inflammation in conditions like AIDP/Guillain-Barré syndrome, with the goal of protecting nerves and reducing symptoms.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11443898

• KCTD11-related CMT neuropathy: uncovering how it damages nerves

  We are studying a genetic form of Charcot–Marie–Tooth disease to understand what goes wrong in nerves and support future treatments.

  NIH research Albany Medical College · Albany, United States · NIH-11438330

• Arginase-positive monocytes help protect optic nerve cells after eye injury

  A study at a major university will explore how certain immune cells in the eye might protect retinal cells after traumatic injury or inflammation, aiming to turn inflammation into healing rather than damage.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11418886

• Trans-BBB AAV9 gene therapy for CNS symptoms in kids with MPS I

  A gene therapy designed to get an IDUA enzyme into the brain to help children with MPS I who have brain-related problems.

  NIH research Neurogt, INC. · Chapel Hill, UNITED STATES · NIH-11417197

• Novel pain biomarker for neuropathy that could guide therapy

  A study to develop and test a biomarker that reflects how well peripherally acting pain medicines work for people with painful peripheral neuropathy.

  NIH research Lasmed, LLC · Mountain View, United States · NIH-11416173

• Ksr2 and obesity-related hearing loss in a mouse model: what it means for veterans

  This project studies how obesity and type 2 diabetes affect hearing using a mouse model to identify ways to protect hearing in people with metabolic problems.

  NIH research VA Loma Linda Healthcare System · Loma Linda, United States · NIH-11411893

• Auricular vagus nerve stimulation to help HIV-related nerve pain in older adults

  A new, non-invasive brain-nerve stimulation approach is being tested to help older adults living with HIV who have nerve pain.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11411053

• Longitudinal study of how body-sense relates to chemotherapy nerve damage

  This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11398026

• Understanding how early nerve excitement during chemotherapy leads to painful nerve damage

  A cancer treatment study looks at why the nerve pain some patients get after paclitaxel may develop, by studying how nerves react during the infusion.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11396222

• HIV Tat and nerve pain in people with HIV: how immune pathways may drive HIV-related neuropathy

  A patient-facing look at a grant studying how a protein from HIV (Tat) may trigger nerve pain in people with HIV through immune pathways, with findings that could lead to new treatments.

  NIH research University of New England · Biddeford, United States · NIH-11391149

• Modulating the DNA Repair System to Protect Nerve Cells After Eye Injury

  A physician-scientist at Stanford is testing whether tweaking the DNA damage repair process can keep retinal nerve cells alive after optic nerve injury to prevent vision loss.

  NIH research Stanford University · Stanford, United States · NIH-11387494

• How spinal cord stimulation may relieve painful diabetic neuropathy

  This study explores whether spinal cord stimulation can reduce pain and improve nerve health in adults with painful diabetic neuropathy.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11384398

• LDT to Support Clinical Evaluation of a Drug for Painful Diabetic Neuropathy

  A lab-developed test is being developed to help tailor a drug treatment for people with painful diabetic neuropathy by matching it to patients’ biological markers.

  NIH research Plumeria Therapeutics, INC. · Plainsboro, UNITED STATES · NIH-11384238

• TLR-driven nerve fiber loss in autoimmune-related neuropathy

  A research project tests how immune signals in the skin’s nerves may cause loss of tiny nerve fibers in people with autoimmune-related neuropathy.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11382184

• A new screen for chemotherapy-related nerve problems in young children

  A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.

  NIH research Yale University · New Haven, United States · NIH-11381211

• Understanding nerve damage in Spinocerebellar Ataxia Type 3

  A study in people with SCA3 explores how the disease affects the peripheral nerves and what that means for symptoms like numbness or weakness.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11381061

• Noninvasive brain stimulation to relieve chemotherapy-induced nerve pain in cancer patients

  A small study will test if a non-invasive brain stimulation treatment can reduce painful nerve pain from cancer drugs, with attention to diverse patients who often experience this pain.

  NIH research Morgan State University · Baltimore, United States · NIH-11377965

• Enteric nerve cell loss linked to high-fat diets

  Aims to understand how a Western fat diet may damage nerve cells in the gut and cause constipation, through studies in mice, animal cells, and humangut tissue.

  NIH research Emory University · Atlanta, United States · NIH-11377475

• AIBP-based protection for nerves in glaucoma

  This grant tests whether boosting a cholesterol-regulating protein (AIBP) can protect eye nerve cells from glaucoma-related damage in humans.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11369818

• AAV gene therapy to treat MPS IIIC neuropathy

  A specialized gene therapy using an AAV9 vector is being developed to address the brain and nerve damage in people with MPS IIIC.

  NIH research Neurogt, INC. · Chapel Hill, UNITED STATES · NIH-11369132

• How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain

  A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.

  NIH research University of New England · Biddeford, United States · NIH-11365153

• AXON: Uncovering how eye nerve fibers break in glaucoma

  A study at Emory will use advanced imaging and AI to watch eye nerve fibers over time in people with glaucoma to understand what kinds of mechanical stress cause injury.

  NIH research Emory University · Atlanta, United States · NIH-11365005

• Using AIBP to protect the optic nerve in glaucoma

  Researchers aim to boost a protein called AIBP to reduce inflammation and protect retinal nerve cells in people with glaucoma.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11352275

• Axonal transport and chemotherapy-related nerve pain

  This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11350880

• Wireless, dissolving implants to help the diaphragm recover after phrenic nerve injury

  A new therapy uses a wireless, dissolvable implant to deliver targeted electrical stimulation to speed diaphragm nerve recovery in people with phrenic neuropathy.

  NIH research Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · Chicago, United States · NIH-11345643

• Daily home-based TENS for painful CIPN: phase III confirmatory trial

  A big, multi-site study will test whether a home-based, wireless TENS device can relieve painful chemotherapy-induced peripheral neuropathy in cancer patients.

  NIH research University of Rochester · Rochester, United States · NIH-11339044

• Regenerative ideas for nerve health in Giant Axonal Neuropathy (GAN) through retinoic acid signaling

  A patient-facing look at a research project that aims to improve nerve health in GAN by boosting a vitamin A-related signaling pathway.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11330543

• Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy

  A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11328854

• Objective tools to manage auditory neuropathy in children

  This project will create easy-to-use tests that show how the hearing nerve is working and help guide treatment for infants and young children with auditory neuropathy.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11325724

• Non-opioid pain relief for chemotherapy-related nerve pain using CART II

  A study tests a brain-acting peptide called CART II to help reduce pain from chemotherapy-induced nerve damage without opioids.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11325439

• New ways to understand and treat vision loss after eye radiation

  This project develops a new animal model and tests possible treatments for optic nerve damage that can cause vision loss after radiation for uveal melanoma.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11312563

• New oral TAK1 inhibitor to help with chemotherapy-related nerve pain

  A new oral drug candidate aims to prevent or lessen nerve damage and pain caused by certain chemotherapy treatments in cancer patients.

  NIH research Eydis Bio, INC. · Durham, United States · NIH-11312109

• New treatments for inherited optic atrophy using a primate model

  This project uses a rhesus macaque model of OPA1-related inherited optic atrophy to speed development of better treatments for people with vision loss from this condition.

  NIH research University of California at Davis · Davis, United States · NIH-11304502

• Restoring vision loss in familial dysautonomia

  This project tests a pill-like drug and a local gene therapy to try to protect and restore sight for people with familial dysautonomia.

  NIH research Schepens Eye Research Institute · Boston, United States · NIH-11302641

• Remotely Delivered Tai Chi to Help Older GI Cancer Patients with Chemotherapy-Related Nerve Pain

  A study will test a home-based Tai Chi program to ease nerve pain and improve function for GI cancer patients aged 65 and older who are experiencing chemotherapy-related neuropathy.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11301594

• Understanding HIV-related sensory nerve damage and painful nerve changes

  Researchers are tracking how sensory nerve endings change in HIV-related nerve pain and testing whether blocking nerve-growth signals like NGF can stop harmful nerve sprouting.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11300742

Related topics

Quick answers

How many Neuropathy clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (15 trials), France (3 trials), Switzerland (2 trials), Denmark (1 trial), United Arab Emirates (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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