Cardiovascular risk from a detailed CT calcium score analysis using AI
Official title: Cardiovascular risk from comprehensive evaluation of the CT calcium score exam
Funded at Case Western Reserve University · NIH-11309615 · Data updated 2026-11-12
A patient-friendly study using AI to analyze CT calcium scores and fat in the chest to better predict who might have a future heart event.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | March 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $734,595 |
| NIH project number | 5R01HL165218-04 |
| Project ID | NIH-11309615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults undergoing CT calcium scoring who have or are at risk for ASCVD, including diverse populations such as African American individuals.
✕Less likely to help
Patients without CT calcium scoring data or with non-cardiovascular conditions may not benefit.
What this research studies
This project uses machine learning to look at calcium buildup in the heart arteries and fat around the heart on CT calcium score scans. By combining features like calcifications, fat volume, and tissue density, it aims to improve prediction of major heart events so doctors can tailor prevention and counseling. The goal is to identify high-risk phenotypes and guide personalized preventive therapies, while considering costs and potential side effects. Results could lead to better explanations for patients about their risk and clearer decisions about lifestyle changes and medications.
Why it matters
Potential benefit: If successful, patients could receive more accurate risk forecasts and personalized prevention plans.
How similar studies have gone: Preliminary evidence suggests that combining calcifications with fat measurements can improve risk prediction beyond the Agatston score.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Wilson, David Lynn — Case Western Reserve University
- Study coordinator: Wilson, David Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.