Examining how alcohol affects sexual decision-making and testing an intervention

Alcohol and "Heat of the Moment" Sexual Decision Making Among MSM: Identifying Mechanisms of Sexual Risk and Promoting Behavior Change Through Brief Intervention

NA · Boston University Charles River Campus · NCT05729256

This study tests how drinking alcohol affects sexual choices and tries a new method to help men who have sex with men make safer decisions about sex.

Quick facts

PhaseNA
Study typeInterventional
Enrollment354 (estimated)
Ages18 Years and up
SexMale
SponsorBoston University Charles River Campus (other)
Locations1 site (Boston, Massachusetts)
Trial IDNCT05729256 on ClinicalTrials.gov

What this trial studies

This study investigates the relationship between heavy alcohol consumption and sexual decision-making, particularly focusing on condomless anal intercourse (CAI) among men who have sex with men (MSM). It aims to understand how alcohol and arousal influence risky sexual behaviors in real-life situations. The study employs an experience sampling method to gather data and tests a brief intervention designed to reduce alcohol use and its impact on sexual risk-taking. By addressing these factors, the research seeks to develop effective strategies for HIV prevention.

Who should consider this trial

Good fit: Ideal candidates are cisgender men aged 18 and older who have engaged in condomless anal intercourse and heavy drinking in the past three months.

Not a fit: Patients who are HIV-infected, currently using PrEP, or in exclusive monogamous relationships may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved behavioral interventions that reduce HIV transmission risk among heavy drinking MSM.

How similar studies have performed: While there have been limited interventions addressing alcohol in sexual risk reduction, this study's specific approach is relatively novel and untested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* At least 18 years of age
* Cisgender man who has had condomless anal intercourse with another man in the past 3 months
* Engaged in heavy drinking (assessed by either weekly National Institute on Alcohol Abuse and Alcoholism guidelines \[\> 14 for men\], and/or a heavy drinking episode in the past month \[\> 4 drinks on an occasion\])
* Has a smartphone

Exclusion Criteria:

* HIV-infection
* Currently using PrEP
* In an exclusive monogamous sexual relationship
* History of bipolar disorder, schizophrenia, other psychotic disorder, or current suicidal intent
* Current treatment for alcohol use disorder or substance use disorder
* Unable to provide one or more individuals who can serve as an alternate contact

Where this trial is running

Boston, Massachusetts

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Alcohol Drinking, Sex, Unsafe, Hiv

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.