Exercise and biological samples to understand alcohol-related liver disease
Official title: Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent Mechanism
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11232483 · Data updated 2026-11-12
A patient-focused program from Cleveland Clinic aims to study alcohol-related liver disease by collecting blood, urine, saliva, and PBMC samples from patients and from heavy drinkers and healthy controls.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 15, 2016 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $340,070 |
| NIH project number | 2P50AA024333-11 |
| Project ID | NIH-11232483 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with various stages of alcohol-related liver disease, heavy drinkers without liver disease, and non-drinking healthy controls.
✕Less likely to help
Patients with conditions not related to alcohol use or liver disease may not directly benefit.
What this research studies
This grant supports a Clinical Core that collects and preserves biological samples from people with alcohol-related liver disease, heavy drinkers, and healthy controls to enable research on biomarkers and immune function. Researchers will use these samples to explore how biomarkers in blood, saliva, or urine relate to disease severity and response to therapies. The program builds on existing sample repositories and data to facilitate future translational studies that could improve diagnosis, prognosis, and treatment for ALD.
Why it matters
Potential benefit: If successful, the work could lead to biomarkers and better patient-tailored therapies for alcohol-related liver disease.
How similar studies have gone: Similar biorepositories and biomarker studies have advanced understanding in ALD, but this core emphasizes integrated clinical samples and data.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Dasarathy, Srinivasan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dasarathy, Srinivasan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.