How traumatic stress affects alcohol drinking in men and women
Official title: Sensitivity and resilience to increased alcohol drinking in males and females following traumatic stress
Funded at Oregon Health & Science University · NIH-10832582 · Data updated 2026-11-12
This study is looking at how stress from trauma affects drinking habits in men and women differently, using animal models to explore the brain's role in this relationship, with the goal of helping people who struggle with both PTSD and alcohol use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 1, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $373,309 |
| NIH project number | 5R01AA028680-05 |
| Project ID | NIH-10832582 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced traumatic stress and may be struggling with alcohol use disorders.
✕Less likely to help
Patients who do not have a history of trauma or alcohol use issues may not benefit from this research.
What this research studies
This research investigates the relationship between traumatic stress and alcohol consumption, focusing on how these factors interact differently in males and females. Using an animal model, the study examines how exposure to stress influences drinking behavior and anxiety levels. The researchers aim to understand the biological mechanisms behind these behaviors, particularly looking at specific proteins in the brain that may contribute to increased alcohol intake following stress. By identifying these differences, the research hopes to shed light on the comorbidity of PTSD and alcohol use disorder.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals suffering from PTSD and alcohol use disorders by targeting the underlying biological mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding the links between stress and alcohol consumption, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Ryabinin, Andrey E — Oregon Health & Science University
- Study coordinator: Ryabinin, Andrey E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.