Using Neuropeptide S to reduce anxiety and alcohol consumption
Activation of the Oxytocin System by Neuropeptide S to Generate Anxiolysis and Curb Alcohol Drinking
['FUNDING_OTHER'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-10838740
This study is looking at how a substance called Neuropeptide S might help people with alcohol dependence feel less anxious and drink less, especially during withdrawal, which could lead to new treatments for those struggling with alcohol use.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10838740 on ClinicalTrials.gov |
What this research studies
This research investigates how Neuropeptide S (NPS) can help reduce anxiety and alcohol consumption in individuals with alcohol dependence. By activating the oxytocin system in the brain, the study aims to alleviate the heightened anxiety experienced during alcohol withdrawal, which often leads to increased drinking. The approach involves preclinical models to assess the anxiolytic effects of NPS and its potential to decrease the motivation to consume alcohol. If successful, this research could lead to new therapeutic options for those struggling with alcohol use disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing alcohol dependence or withdrawal symptoms.
Not a fit: Patients who do not have issues with alcohol dependence or are not experiencing withdrawal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for individuals with alcohol dependence, helping to reduce anxiety and alcohol consumption.
How similar studies have performed: While the specific effects of Neuropeptide S on alcohol drinking have not been extensively studied, preclinical data suggest promising anxiolytic effects, indicating potential for success.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TUNSTALL, BRENDAN — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: TUNSTALL, BRENDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alcohol withdrawal syndrome