Microbiota Interventions for Accelerated Aging in People with HIV on Alcohol

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, double-blind, crossover trial, adults with HIV who have recent alcohol use receive either Limosilactobacillus reuteri or blueberry extract for four weeks, then switch after a six-week washout. The study compares changes in immune senescence biomarkers within the same participant to see which intervention may influence aging-related immune changes. It is a mechanistic study focusing on immune aging rather than disease treatment, using GRAS supplements and a crossover design to control for individual differences. Biospecimens and clinical assessments occur at baseline and week 4 of each intervention period. Recruitment targets HIV care programs and community outreach in New Orleans.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥40 years
* People with HIV
* Recent alcohol use defined as ≥42 grams in the prior week and positive urine ethyl glucuronide (EtG)

Exclusion Criteria:

* Probiotic use in past 3 months
* Recent antibiotics or immunosuppressives
* Allergy to study products
* Pregnancy or breastfeeding
* Inability to comply

Where it's running

• LSU Health
  New Orleans, Louisiana, United States Recruiting

Study contacts

• Principal investigator: David A Welsh, MD — LSU Health New Orleans
• Study coordinator: David A Welsh, MD
• Email: dwelsh@lsuhsc.edu
• Phone: United States

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.