Analyzing Blood Changes in Patients with Acute Coronary Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to analyze various factors in the blood of patients diagnosed with acute coronary syndrome (ACS), including cell growth factors, inflammatory markers, metabolites, and plasma proteins. By comparing these factors in ACS patients to a control group without coronary artery disease, the researchers hope to identify significant changes that correlate with disease prognosis. Blood samples will be collected from participants within 24 hours of their hospital admission to ensure timely analysis. The study employs multi-omics approaches to provide a comprehensive understanding of the biological changes associated with ACS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For ACS group STEMI

* cTn\>99th ULN or CK-MB\>99th ULN
* ST-segment elevation with a convex upward morphology
* in conjunction with one or more of the following conditions: persistent ischemic chest pain; echocardiographic evidence of abnormal segmental ventricular wall motion; or abnormal coronary angiography findings.

NSTEMI

* cTn\>99th ULN or CK-MB\>99th ULN
* accompanied by one or more of the following situations: persistent ischemic chest pain; new ST-segment depression or low and inverted T waves; echocardiography showing segmental ventricular wall motion abnormalities; abnormal coronary angiography.

UA

* cTn normal
* ischemic chest pain with an electrocardiogram showing transient ST-segment depression or flattened and inverted T waves
* evidence of coronary artery stenosis (e.g., CTA demonstrating ≥ 50% stenosis) For CCS group
* Clinical Diagnosis Consistent with CCS Categories, meet any one of the following clinical scenarios: Stable Angina Pectoris, Ischemic Cardiomyopathy, Post-ACS Stable Phase, Long-Term CAD Management, Vasospastic or Microvascular Disease, Asymptomatic CAD
* Laboratory and Imaging Confirmation: Resting ECG without ST-segment elevation or dynamic changes (excluding ACS), cTn normal or stable (no acute myocardial injury), ≥50% luminal stenosis in ≥1 epicardial coronary artery For control group
* Patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy

Exclusion Criteria:

* Lactating or pregnant women
* Patients with malignant neoplasms
* Severe hepatic/renal dysfunction
* Severe hematological disorders
* Autoimmune diseases

Where it's running

• Lishui Central Hospital
  Lishui, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Chao Niu, Doctor
• Email: davidduoduo@163.com
• Phone: 86+18267806867

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.