Analyzing Blood Changes in Patients with Acute Coronary Syndrome
A Study on Integrated Multi-Omics and Multi-Factor Analysis of Peripheral Blood in Patients With Acute Coronary Syndrome
This study looks at blood samples from patients with acute coronary syndrome to see how their blood factors differ from those without heart disease, hoping to find clues about the condition's outlook.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 310 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Second Affiliated Hospital of Wenzhou Medical University Academic / other |
| Locations | 1 site (Lishui, Zhejiang) |
| Trial ID | NCT06955143 on ClinicalTrials.gov |
What this trial studies
This study aims to analyze various factors in the blood of patients diagnosed with acute coronary syndrome (ACS), including cell growth factors, inflammatory markers, metabolites, and plasma proteins. By comparing these factors in ACS patients to a control group without coronary artery disease, the researchers hope to identify significant changes that correlate with disease prognosis. Blood samples will be collected from participants within 24 hours of their hospital admission to ensure timely analysis. The study employs multi-omics approaches to provide a comprehensive understanding of the biological changes associated with ACS.
Who should consider this trial
Good fit: Ideal candidates for this study include patients diagnosed with ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), or unstable angina.
Not a fit: Patients with stable coronary artery disease or other forms of heart disease not related to acute coronary syndrome may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic tools and targeted therapies for patients with acute coronary syndrome.
How similar studies have performed: Other studies have shown success in using multi-omics approaches to analyze blood changes in cardiovascular conditions, suggesting potential for meaningful insights in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For ACS group STEMI * cTn\>99th ULN or CK-MB\>99th ULN * ST-segment elevation with a convex upward morphology * in conjunction with one or more of the following conditions: persistent ischemic chest pain; echocardiographic evidence of abnormal segmental ventricular wall motion; or abnormal coronary angiography findings. NSTEMI * cTn\>99th ULN or CK-MB\>99th ULN * accompanied by one or more of the following situations: persistent ischemic chest pain; new ST-segment depression or low and inverted T waves; echocardiography showing segmental ventricular wall motion abnormalities; abnormal coronary angiography. UA * cTn normal * ischemic chest pain with an electrocardiogram showing transient ST-segment depression or flattened and inverted T waves * evidence of coronary artery stenosis (e.g., CTA demonstrating ≥ 50% stenosis) For CCS group * Clinical Diagnosis Consistent with CCS Categories, meet any one of the following clinical scenarios: Stable Angina Pectoris, Ischemic Cardiomyopathy, Post-ACS Stable Phase, Long-Term CAD Management, Vasospastic or Microvascular Disease, Asymptomatic CAD * Laboratory and Imaging Confirmation: Resting ECG without ST-segment elevation or dynamic changes (excluding ACS), cTn normal or stable (no acute myocardial injury), ≥50% luminal stenosis in ≥1 epicardial coronary artery For control group * Patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy Exclusion Criteria: * Lactating or pregnant women * Patients with malignant neoplasms * Severe hepatic/renal dysfunction * Severe hematological disorders * Autoimmune diseases
Where this trial is running
Lishui, Zhejiang
- Lishui Central Hospital — Lishui, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Chao Niu, Doctor
- Email: davidduoduo@163.com
- Phone: 86+18267806867
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.