Condition

Chest Pain clinical trials and research

• 21Clinical trials
• 7NIH research projects
• 14Countries

Newest Chest Pain clinical trials

All recruiting trials (21)

• Smartwatch 9-lead ECG vs 12-lead ECG to detect STEMI in chest pain patients

  We are testing whether a smartwatch ECG can help diagnose STEMI in people with chest pain.

  Recruiting Hospital General Universitario Santa Lucia · Cartagena, Murcia · NCT07780942

• ML-based diagnosis of blocked arteries in patients with a left bundle branch block

  Doctors are testing a machine learning tool that uses digital ECGs to see if a blocked coronary artery is present in patients with a left bundle branch block.

  Recruiting Konya City Hospital · Konya, Karatay · NCT07620119

• Hormones, Pain, and Exercise: Sports Bras for Full-Busted Women

  This study tests whether specially designed sports bras can reduce neck, shoulder, arm, and back pain in full-busted women, and whether hormones, inflammation, or brain changes affect pain.

  Recruiting Phase 1 University of Houston · Houston, Texas · NCT07579182

• Chest pain screening for hidden cardiac amyloidosis

  We will test whether men over 65 who have chest pain but no coronary artery disease might have hidden cardiac amyloidosis using blood and urine tests, ECG and echocardiography, bone scintigraphy, and sometimes a heart biopsy.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07435168

• Freesolve resorbable magnesium scaffold vs. Xience stent for up to two new heart artery lesions

  This trial tests whether the Freesolve resorbable magnesium scaffold works as well as the Xience drug-eluting stent for treating up to two new coronary artery lesions in adults.

  Recruiting at 3 sites Teleflex · Washington D.C., District of Columbia and 2 other locations · NCT07258290

• AI to improve telephone triage for emergency calls at CCUE Andalucía

  This project tests AI tools to help emergency call operators spot life-threatening problems like cardiac arrest, stroke, severe breathing trouble, and chest pain.

  Recruiting Centro de Emergencias Sanitarias 061 Andalucía · Málaga, Málaga · NCT07247669

• AI-assisted interpretation of chest pain CT in the emergency department

  A pragmatic randomized trial tests whether an AI tool (Angiomics) helps emergency physicians interpret coronary CT angiography in adults with acute chest pain.

  Recruiting Yonsei University · Seoul · NCT07235657

• ECG-less CT angiogram for people with high-troponin chest pain

  This trial will test whether an ECG-less CT angiogram can quickly rule out life-threatening causes in people who come to the ER with chest pain and elevated troponin levels.

  Recruiting Universitair Ziekenhuis Brussel · Jette · NCT07192965

• Har Score: Prioritizing Chest Pain Calls by Emergency Dispatch to See if Access Delays Can Be Reduced

  This observational study tests whether using the HAR score to prioritize chest-pain calls at emergency dispatch centers helps identify high-risk patients sooner.

  Recruiting at 3 sites Centre Hospitalier le Mans · Angers and 2 other locations · NCT06859021

• Differences in chest pain symptoms between diabetic and non-diabetic patients

  This study looks at how chest pain symptoms differ between diabetic and non-diabetic patients who have had a heart attack to see if diabetes affects their ability to feel pain.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT06718374

• Examining the role of general practice follow-up for patients with chest pain

  This study looks at how follow-up care from a general doctor affects the health and well-being of people who had chest pain and were treated in the emergency room.

  Recruiting Centre Hospitalier Emile Roux · Le Puy-en-Velay · NCT06693063

• Comparing heart imaging techniques for coronary artery disease

  This study is testing if a new heart imaging method can better identify problems in patients suspected of having coronary artery disease compared to a traditional imaging technique.

  Recruiting Semmelweis University · Budapest, Budapest · NCT06670768

• Using virtual reality to treat non-cardiac chest pain

  This study is testing whether virtual reality can help people with non-cardiac chest pain feel less pain and anxiety while improving their quality of life.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06262126

• Vericiguat for small-vessel (microvascular) heart disease causing stable chest pain

  This trial gives vericiguat to people aged 40–75 with chest pain from coronary microvascular dysfunction to see if it improves blood flow in the heart on stress CMR.

  Recruiting The University of Hong Kong · Hong Kong · NCT06239974

• Model for predicting causes of chest pain

  This study is trying to create a tool that helps doctors better understand the causes of chest pain in patients so they can provide the right treatment more quickly.

  Recruiting Beijing Anzhen Hospital · Beijing, Chaoyang · NCT06196307

• Nurse-led management of chest pain in the emergency department

  This study tests if having specially trained nurses manage chest pain in the emergency department can help patients feel better compared to regular medical care.

  Recruiting University Hospital, Grenoble · Grenoble, Grenoble · NCT06149819

• Evaluating outpatient care versus hospitalization for patients with chest pain

  This study is testing whether a quick outpatient care plan for patients with moderate chest pain is better than being hospitalized for treatment.

  Recruiting at 3 sites Wake Forest University Health Sciences · Detroit, Michigan and 2 other locations · NCT05897632

• Using magnetocardiography to identify heart attacks

  This study is testing if a new noninvasive heart scan method can help doctors better identify heart attacks in people with chest pain and healthy volunteers.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT05896826

• Decision support for patients with chest pain in emergency settings

  This study is testing a new system that uses machine learning to help emergency medical teams better understand and treat patients with chest pain.

  Recruiting at 3 sites Vastra Gotaland Region · Kungsbacka, Region Halland and 2 other locations · NCT05767619

• Investigating new cardiac biomarkers for diagnosing acute coronary syndrome

  This study is testing new blood markers to see if they can help doctors better diagnose acute coronary syndrome in patients who might be having a heart attack.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT02355457

• Evaluating sex differences in causes of chest pain

  This study is trying to find out why women and men with normal heart arteries experience chest pain differently, to help improve how we test and treat these symptoms in women.

  Recruiting Stanford University · Stanford, California · NCT00823563

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• ECG-BASED smart tools to quickly classify chest pain in emergency care

  A patient-focused project to use advanced ECG analysis and machine learning to quickly identify heart problems in people with chest pain when they arrive at the ER.

  NIH research University of Rochester · Rochester, United States · NIH-11550067

• How emergency doctors’ decisions about chest pain affect testing and outcomes

  A study using Medicare data will see if doctors who tend to admit chest-pain patients to the hospital lead to more tests and different outcomes for those patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11371961

• Using ECGs to find hidden heart attacks in people with chest pain

  This project is creating smart ECG tools to quickly spot heart attacks that don't show the classic ST-elevation in people who come to the emergency room with chest pain.

  NIH research University of Rochester · Rochester, United States · NIH-11292312

• MACE-Alert: AI tools to help triage chest pain in the emergency department

  An AI-powered system and a patient-facing chat tool aim to improve how emergency teams evaluate and triage people with chest pain.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11288452

• Electrocardiographic warning system to speed up chest-pain care (ECG-SMART 2)

  A research project is testing new ECG-based computer tools to quickly and safely identify patients with potentially serious chest pain in emergency departments.

  NIH research University of Rochester · Rochester, United States · NIH-11099852

• Evaluating a new approach for managing chest pain patients in outpatient settings

  This study is testing a new way to help people with chest pain who aren't at high risk by letting them go home from the emergency room instead of staying in the hospital, and then checking in with them within three days to make sure they're doing okay and to manage any heart health concerns.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11003318

• Improving ECG methods to quickly identify heart issues in chest pain patients

  This study is working on a new tool to help doctors quickly and accurately check patients with chest pain in the emergency room, using advanced technology to spot heart issues that might be missed by regular tests, so they can provide faster and better care for you.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10893324

Related topics

Quick answers

How many Chest Pain clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (5 trials), France (3 trials), China (2 trials), Spain (2 trials), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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