Collecting blood samples from heart attack patients to identify new biomarkers
The Harefield Acute Myocardial Infarction Cohort
This study is collecting blood samples from heart attack patients during routine procedures to see if they can find new markers that help us understand heart disease better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Sex | All |
| Sponsor | Royal Brompton & Harefield NHS Foundation Trust Academic / other |
| Locations | 2 sites (Harefield, Middlesex and 1 other locations) |
| Trial ID | NCT04218344 on ClinicalTrials.gov |
What this trial studies
This project aims to gather blood samples during routine angiogram procedures from patients who have experienced acute coronary syndromes, such as heart attacks. The collected data will include clinical parameters from ECGs, echocardiograms, and MRI scans, which will be analyzed to identify novel biomarkers related to inflammation and micro-organism activity. Follow-up data will be collected through questionnaires at 6 weeks and 6 months post-procedure, with additional updates via phone at one year. The goal is to enhance understanding of heart disease causes and improve treatment strategies.
Who should consider this trial
Good fit: Ideal candidates include patients presenting with ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, unstable angina, and other related conditions undergoing coronary angiography.
Not a fit: Patients who do not provide informed consent or those who do not survive the hospital episode may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment strategies for patients with acute coronary syndromes.
How similar studies have performed: Other studies have shown promise in identifying biomarkers for heart disease, suggesting that this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • All patients presenting to Harefield Hospital through the Primary Percutaneous Coronary Intervention programme, with ST-segment elevation myocardial infarction, non ST-segment elevation myocardial infarction, unstable angina, Tako Tsubo syndrome, spontaneous coronary artery dissection and acute myocarditis, with the intention to assess with coronary angiography. Exclusion Criteria: * Patients will be able to self-exclude if they do not provide full informed consent * Every effort will be made to obtain informed consent from all patients. * Patients who do not survive the hospital episode will undergo a Professional or Personal Consultee process of assumed consent.
Where this trial is running
Harefield, Middlesex and 1 other locations
- Harefield Hospital — Harefield, Middlesex, United Kingdom (Recruiting)
- Royal Brompton and Harefield NHS Foundation Trust — Uxbridge, Middlesex, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.