Optimizing long-term prevention of cardiovascular disease after acute coronary syndrome
Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD (GOLDEN). A Prospective Observational Study of Long-term Outcomes.
This study tests if starting a complete medication plan right away for people hospitalized with heart disease can help prevent serious heart problems better than the usual gradual approach.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5586 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam) |
| Trial ID | NCT06637657 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the effectiveness of a 'first-time-right' pharmacological treatment strategy for patients hospitalized with coronary artery disease. It compares this approach, which involves immediate initiation of a comprehensive medication plan, to the current practice of incremental titration of medications. The study aims to determine if the new strategy leads to a reduction in major adverse cardiovascular events over a 36-month period. Participants will be monitored through routine clinical visits and online questionnaires to assess outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years who have experienced an acute coronary syndrome event or coronary revascularization.
Not a fit: Patients who are pregnant, breastfeeding, or on dialysis may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of recurrent cardiovascular events in patients with coronary artery disease.
How similar studies have performed: While similar approaches have been discussed in guidelines, this specific 'first-time-right' strategy has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years of age (no upper limit) * Coronary event, i.e. ACS or coronary revascularisation * Able to provide informed consent Exclusion Criteria: * (short-term planned) pregnancy or breast feeding * Dialysis
Where this trial is running
Amsterdam
- Amsterdam UMC — Amsterdam, Netherlands (Recruiting)
Study contacts
- Principal investigator: Harald T. Jorstad, dr. — Amsterdam UMC
- Study coordinator: Manon van den Bogaart, drs.
- Email: m.vandenbogaart@amsterdamumc.nl
- Phone: 003120 5660703
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.