Clinical trial Recruiting at 1 site Observational Ages 18 and up

Optimizing long-term prevention of cardiovascular disease after acute coronary syndrome

Official title: Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD (GOLDEN). A Prospective Observational Study of Long-term Outcomes.

Run by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · NCT06637657 · Data updated 2026-11-12

This study tests if starting a complete medication plan right away for people hospitalized with heart disease can help prevent serious heart problems better than the usual gradual approach.

More Acute Coronary Syndrome trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment5586 (estimated)
SponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Academic / other
Locations1 site (Amsterdam)
StatusRecruiting
StartedJuly 9, 2024
Main results expectedJanuary 2029
Study endsJanuary 2029
Registry record updatedOctober 15, 2024
Trial IDNCT06637657 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 18 years who have experienced an acute coronary syndrome event or coronary revascularization.

Probably not a fit

Patients who are pregnant, breastfeeding, or on dialysis may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness of a 'first-time-right' pharmacological treatment strategy for patients hospitalized with coronary artery disease. It compares this approach, which involves immediate initiation of a comprehensive medication plan, to the current practice of incremental titration of medications. The study aims to determine if the new strategy leads to a reduction in major adverse cardiovascular events over a 36-month period. Participants will be monitored through routine clinical visits and online questionnaires to assess outcomes.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the risk of recurrent cardiovascular events in patients with coronary artery disease.

How similar studies have gone: While similar approaches have been discussed in guidelines, this specific 'first-time-right' strategy has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* \>18 years of age (no upper limit)
* Coronary event, i.e. ACS or coronary revascularisation
* Able to provide informed consent

Exclusion Criteria:

* (short-term planned) pregnancy or breast feeding
* Dialysis

Where it's running

  • Amsterdam UMC
    Amsterdam, Netherlands
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.