OPT-CAD–guided timing for switching to a P2Y12 inhibitor alone after PCI in acute coronary syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares an OPT-CAD score–guided de-escalation strategy to standard dual antiplatelet therapy after percutaneous coronary intervention. Patients classified as low risk by OPT-CAD would be switched to P2Y12 monotherapy after 1 month, while higher-risk patients would switch after 3 months. Eligible participants are adults (18–80) with ACS who received at least one drug-eluting stent and are able to complete OPT-CAD scoring, with several exclusions including high bleeding risk and left main PCI. The main goal is to balance ischemic and bleeding outcomes using a risk-stratified timing approach informed by a score derived in a Chinese population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients with ages of 18-80 years;
2. Patients with clinically diagnosed ACS who have undergone at least one DES implantation;
3. Individuals capable of completing the OPT-CAD scoring calculation;
4. Researchers assessing that participants can tolerate at least a 12-month duration of DAPT therapy;
5. Written informed consent provided.

Exclusion Criteria:

1. Left main coronary artery lesion PCI;
2. Allergy to study drugs such as aspirin, clopidogrel, or ticagrelor;
3. Meeting 1 major or 2 minor criteria for high bleeding risk according to the ARC-HBR criteria;
4. Anticipated need for revascularization or surgical intervention within 12 months;
5. Severe ischemia or hemorrhage events during the current hospitalization;
6. Life expectancy of other serious diseases is less than 1 year;
7. Pregnant or women of childbearing age who intend to conceive within 1 year;
8. Participation in other clinical trials while still under observation;
9. Researchers considering ineligibility for enrollment.

Where it's running

• General Hospital of Northern Theater Command
  Shenyang, Liaoning, China Recruiting

Study contacts

• Study coordinator: Yi Li, PhD
• Email: doctorliyi@126.com
• Phone: +86-24-28897309

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.