Using cardiac MRI before invasive coronary angiography for suspected NSTEMI patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot study, conducted at Karolinska University Hospital, aims to evaluate the effectiveness of performing cardiac MRI (CMR) prior to planned invasive coronary angiography (ICA) in patients suspected of having non-ST-elevation myocardial infarction (NSTEMI). The study will include 150 patients, both with and without a history of myocardial infarction, and will utilize standard CMR protocols alongside novel techniques such as magnetic resonance angiography. The findings from the CMR will be kept blinded from the treating physicians to ensure unbiased clinical decisions, except in cases of unexpected adverse findings. The goal is to determine if a CMR-first approach can accurately diagnose NSTEMI and potentially reduce the need for ICA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥18 years of age Suspected NSTEMI (signs and symptoms suggest of ACS with initial ECG showing no ST-elevation)
* Planned ICA where CMR can be performed without delaying ICA
* Able to provide written informed consent

Exclusion Criteria:

* Contraindications for CMR examination with gadolinium contrast (claustrophobia, eGFR \<30ml/min/1.73m2, contrast allergy, and non-MRI compatible implants)
* Arrythmias which hinder CMR examination
* Previous CABG
* Hemodynamic instability
* Myocardial infarction \<6 months prior to inclusion

Where it's running

• Karolinska University Hospital
  Stockholm, Sweden, Sweden Recruiting

Study contacts

• Principal investigator: Marcus E Carlsson, Professor — Karolinska Insitutet and Karolinska University Hospital
• Study coordinator: Daniel F Andersson, M.D.
• Email: daniel.f.andersson@ki.se
• Phone: +46 702319573

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.