High-dose statin therapy for patients with acute coronary syndrome
The Protective Effect of Early High Dose High-intensity Statins on Cardiovascular and Renal Events in Patients With Acute Coronary Syndrome
This study is testing if giving high doses of statins right away to patients with acute coronary syndrome can improve their heart health during and after their hospital stay.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2500 (estimated) |
| Sex | All |
| Sponsor | Centro Cardiopatici Toscani Academic / other |
| Locations | 1 site (Prato) |
| Trial ID | NCT04087200 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of early high-dose statin therapy on patients admitted for acute coronary syndrome (ACS), including both STEMI and NSTEMI. Patients who are statin-naive or already on statins will receive either atorvastatin or rosuvastatin immediately upon admission, prior to any invasive procedures. The study will track various cardiac and renal parameters during hospitalization and conduct follow-ups one month and one year after discharge to assess outcomes.
Who should consider this trial
Good fit: Ideal candidates include patients experiencing acute coronary syndrome who are scheduled for early invasive strategies.
Not a fit: Patients with contraindications to statin therapy or those who refuse consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of cardiovascular and renal events in patients with acute coronary syndrome.
How similar studies have performed: Other studies have shown promising results with high-dose statin therapy in similar patient populations, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute coronary syndrome (ST elevation and non ST elevation) * Early invasive strategy Exclusion Criteria: * contraindication to statin therapy * refusal of consent
Where this trial is running
Prato
- Cardiology Division, Prato Hospital — Prato, Italy (Recruiting)
Study contacts
- Study coordinator: Anna Toso, MD
- Email: anna.toso@libero.it
- Phone: 00393387982507
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.