High-dose statin therapy for patients with acute coronary syndrome
Official title: The Protective Effect of Early High Dose High-intensity Statins on Cardiovascular and Renal Events in Patients With Acute Coronary Syndrome
Run by Centro Cardiopatici Toscani · NCT04087200 · Data updated 2026-11-12
This study is testing if giving high doses of statins right away to patients with acute coronary syndrome can improve their heart health during and after their hospital stay.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | Centro Cardiopatici Toscani Academic / other |
| Locations | 1 site (Prato) |
| Status | Recruiting |
| Started | December 1, 2016 |
| Main results expected | December 1, 2025 |
| Study ends | December 1, 2026 |
| Registry record updated | September 12, 2019 |
| Trial ID | NCT04087200 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients experiencing acute coronary syndrome who are scheduled for early invasive strategies.
✕Probably not a fit
Patients with contraindications to statin therapy or those who refuse consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effects of early high-dose statin therapy on patients admitted for acute coronary syndrome (ACS), including both STEMI and NSTEMI. Patients who are statin-naive or already on statins will receive either atorvastatin or rosuvastatin immediately upon admission, prior to any invasive procedures. The study will track various cardiac and renal parameters during hospitalization and conduct follow-ups one month and one year after discharge to assess outcomes.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of cardiovascular and renal events in patients with acute coronary syndrome.
How similar studies have gone: Other studies have shown promising results with high-dose statin therapy in similar patient populations, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute coronary syndrome (ST elevation and non ST elevation) * Early invasive strategy Exclusion Criteria: * contraindication to statin therapy * refusal of consent
Where it's running
-
Cardiology Division, Prato Hospital
Prato, Italy Recruiting
Study contacts
- Study coordinator: Anna Toso, MD
- Email: anna.toso@libero.it
- Phone: 00393387982507
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.