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Percutaneous Coronary Intervention clinical trials and research

• 41Clinical trials
• 9NIH research projects
• 1New in 30 days
• 16Countries

Newest Percutaneous Coronary Intervention clinical trials

All recruiting trials (41)

• Pilates breathing vs diaphragmatic breathing after PCI

  This study tests whether Pilates breathing or diaphragmatic breathing helps improve oxygen levels and heart-rate variability in people who just had PCI.

  Recruiting Foundation University Islamabad · Rawalpindi · NCT07872098

• Aspirin 50 mg vs 100 mg with a P2Y12 inhibitor after PCI

  This trial tests whether a 50 mg daily aspirin dose, when used with a P2Y12 inhibitor after PCI, works as well as 100 mg with similar safety for people staying on DAPT for 12 months.

  Recruiting Jilin University · Changchun, Jilin · NCT07846462

• See if stopping long-term aspirin is as good as continuing it in older adults with stable ischemic heart disease

  In adults 65 and older with stable ischemic heart disease, this trial tests whether stopping daily low-dose aspirin is not worse than continuing it.

  Recruiting at 2 sites Phase 4 Odense University Hospital · Copenhagen and 1 other locations · NCT07795398

• Dual antihypertensive combinations after PCI: ARB + thiazide versus ARB + amlodipine

  This trial tests two blood pressure treatment combos after a stent procedure in people with hypertension and coronary disease to see which regimen better controls blood pressure and improves symptoms.

  Recruiting National Medical Research Center for Therapy and Preventive Medicine · Moscow · NCT07683585

• Coronary thrombus modification to reduce microvascular damage during STEMI care

  This study tests whether modifying the clot in the heart arteries during primary PCI can lessen microvascular damage and myocardial injury in STEMI patients.

  Recruiting Odense University Hospital · Odense · NCT07646977

• Long-term P2Y12 inhibitor monotherapy and blood clotting after angioplasty

  This trial will test whether specific P2Y12 drugs and reduced doses given alone keep platelet activity in a safe therapeutic range for people who completed initial dual antiplatelet therapy after PCI.

  Recruiting Phase 3 Cardiocentro Ticino · Lugano, Ch/ti · NCT07582835

• DCB-based PCI vs DES-based PCI in multivessel coronary disease

  This study tests whether using a drug-coated balloon for PCI works as well as drug-eluting stents in people with disease in multiple coronary arteries.

  Recruiting Genoss Co., Ltd. · Ulsan · NCT07539324

• What affects bleeding control and how long you need to lie flat after femoral arterial sheath removal

  We will see if patient and procedure factors can predict how long ICU patients need compression and bed rest after femoral arterial sheath removal to prevent bleeding and hematoma.

  Recruiting National Taiwan University Hospital · Taipei · NCT07469397

• IVUS-based ultrasound method to measure blood flow through narrowed coronary arteries

  This study tests whether an IVUS-derived software can quickly tell if a narrowed coronary artery is reducing blood flow in adults having coronary angiography, without using pressure wires or vasodilator drugs.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07446023

• Doctors' and patients' preferences for PCI implantation devices

  This questionnaire tests what patients who have had PCI and the doctors who treat them prefer between drug-eluting stents and drug-coated balloons.

  Recruiting Xijing Hospital · Xi'an, Shannxi · NCT07378163

• How patients and doctors value different outcomes after coronary stent procedures

  This project asks patients who had a coronary stent (PCI) and the doctors who treat them to rate how important different possible outcomes are to see if their priorities match.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07378137

• Poland registry of procedures to open completely blocked coronary arteries (chronic total occlusions)

  This project will see how well and how safely percutaneous coronary intervention (PCI) works for people in Poland who are having procedures to open chronic total coronary occlusions.

  Recruiting at 21 sites National Institute of Cardiology, Warsaw, Poland · Bialystok and 20 other locations · NCT07330622

• Flozins to prevent contrast-related kidney injury after coronary angiography or PCI

  This project tests whether taking a flozin (empagliflozin or dapagliflozin), short-term or long-term, lowers the chance of contrast-induced acute kidney injury in patients having coronary angiography or PCI.

  Recruiting Collegium Medicum w Bydgoszczy · Bydgoszcz · NCT07231939

• Temporary heart support with the iVAC 2L device during high-risk coronary procedures

  This trial will try the iVAC 2L temporary heart‑support device during high‑risk PCI to help people with severe coronary artery disease stay hemodynamically stable through the procedure.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT07149714

• Inclisiran to prevent heart and limb events after coronary or peripheral artery procedures

  This trial will try a twice-yearly inclisiran injection in adults who just had coronary or peripheral artery procedures to see if it lowers the chance of major heart or limb events.

  Recruiting at 145 sites Phase 4 Duke University · Alexander City, Alabama and 148 other locations · NCT06909565

• Best timing for heparin during radial-access coronary procedures

  This research will test whether giving heparin before inserting the radial sheath instead of after lowers the chance of radial artery occlusion in adults having radial-access coronary angiography or PCI.

  Recruiting University Hospital, Strasbourg, France · Strasbourg, Bas-Rhin · NCT06890312

• Comparing two ways to open chronic total coronary artery blockages: antegrade dissection-and-reentry versus retrograde approach.

  This test will compare whether the antegrade dissection-and-reentry or the retrograde approach works better and is safer for people with difficult chronic total coronary occlusions who need PCI.

  Recruiting at 3 sites National Institute of Cardiology, Warsaw, Poland · Warsaw, Warsaw and 2 other locations · NCT06878729

• Ultrasound-guided pain relief for heart procedures

  This study is testing if using ultrasound to guide a specific pain relief technique can make heart procedures more comfortable for patients.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT06576128

• Registry for patients with kidney disease and heart issues

  This study collects information from adults with kidney disease and heart problems to see how their treatments and outcomes differ, helping us understand their health better.

  Recruiting Queen Mary University of London · London · NCT06521801

• Sirolimus versus paclitaxel coated balloon for small coronary artery lesions

  This compares a sirolimus-coated balloon and a paclitaxel-coated balloon to see which keeps medium-size coronary arteries (2.00–3.00 mm) more open and improves blood flow at 12 months in adults with new coronary lesions.

  Recruiting at 8 sites Fondazione Evidence per Attività e Ricerche Cardiovascolari ONLUS · Mercogliano, Italy/Avellino and 9 other locations · NCT06373601

• Comparing two methods for diagnosing heart conditions in patients with non-ST elevation acute coronary syndrome

  This study is testing if a non-invasive heart scan can safely and effectively diagnose heart conditions in patients with certain types of heart attacks, compared to the traditional invasive method.

  Recruiting at 6 sites Copenhagen University Hospital, Rigshospitalet · Copenhagen, Hellerup and 5 other locations · NCT06101862

• Evaluating 1-year Dual Antiplatelet Therapy after GENOSS® Stent Implantation in Heart Disease Patients

  This study is testing whether a year of dual antiplatelet therapy after getting a GENOSS® stent helps heart disease patients stay healthy and avoid serious heart problems.

  Recruiting Genoss Co., Ltd. · Wŏnju, Gangwon State · NCT06075433

• Evaluating short-term dual antiplatelet therapy after a specific heart stent implantation

  This study is testing whether a short period of dual antiplatelet therapy after getting a specific heart stent can keep patients with coronary artery disease safe and healthy over a year.

  Recruiting Genoss Co., Ltd. · Wŏnju, Gangwon State · NCT06075420

• Using an algorithm to tailor antiplatelet therapy after heart procedures

  This study is testing whether using a special scoring system to decide how long heart patients should take their blood-thinning medication after getting a stent can lead to better health outcomes compared to the usual method.

  Recruiting at 4 sites Insel Gruppe AG, University Hospital Bern · Banja Luka and 3 other locations · NCT05732701

• Investigating risk factors for heart procedures at Beijing Friendship Hospital

  This study is trying to find out what risk factors might affect patients with heart disease who need a specific heart procedure, to help improve their treatment and care.

  Recruiting Beijing Friendship Hospital · Beijing, Beijing Municipality · NCT05728580

• Investigating risk factors in patients with acute coronary syndrome undergoing a procedure

  This study is trying to find out what risk factors affect patients with acute coronary syndrome who are having a heart procedure and how these factors relate to their health outcomes over two years.

  Recruiting Jinan Central Hospital · Jinan, Shandong · NCT05719545

• FAST-guided PCI in STEMI with Multivessel Disease

  This trial tests whether using the FAST technique during PCI in STEMI patients with multivessel disease improves outcomes compared with standard treatment.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT05669222

• Guiding NOAC therapy for patients with acute coronary syndrome after heart procedures

  This study is testing a new combination of heart medications to see if it can help people with acute coronary syndrome avoid serious heart problems without causing more bleeding than standard treatment.

  Recruiting Phase 4 China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT05638867

• Registry for patients undergoing percutaneous coronary intervention

  This study is collecting information from patients with coronary artery disease who have had or will have a heart procedure to see how they do over time and what factors might affect their recovery.

  Recruiting Samsung Medical Center · Seoul · NCT05624905

• Evaluating Nicorandil to Prevent Blood Flow Issues During Heart Procedures

  This study is testing if a medication called nicorandil can help people with high-risk heart plaque maintain better blood flow during heart procedures like stent placement.

  Recruiting Phase 4 Korea University Anam Hospital · Seoul · NCT05427786

• Comparing left atrial appendage occlusion and novel oral anticoagulants in patients with atrial fibrillation undergoing PCI

  This study is testing whether a device that blocks a part of the heart can work better than blood thinners for people with atrial fibrillation who have had heart procedures.

  Recruiting Xijing Hospital · Xi'an, Shannxi · NCT05353140

• Registry collecting data on patients undergoing heart artery procedures

  This study is collecting information from patients who are having heart artery procedures to see how they do during and after their treatment.

  Recruiting Federico II University · Naples · NCT05248165

• Evaluating complete revascularization in patients with multivessel coronary artery disease

  This study is testing if a specific heart procedure can improve health outcomes for people with multiple blocked arteries who experience chest pain or other heart issues.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT05230446

• Using remote ischemic preconditioning to protect kidneys and heart in heart failure patients

  This study is testing if a special treatment called remote ischemic preconditioning can help protect the kidneys and heart of heart failure patients during cardiac procedures.

  Recruiting at 3 sites Phase 2/3 VA Office of Research and Development · Pittsburgh, Pennsylvania and 2 other locations · NCT04982419

• Sequential use of ticagrelor and clopidogrel after heart procedures

  This study is testing if switching between two heart medications, ticagrelor and clopidogrel, can help people with acute coronary syndrome after heart procedures while keeping them safe from bleeding.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04937699

• Comparing a new medication to standard treatment for preventing stomach issues in heart patients on blood thinners

  This study is testing a new medication called tegoprazan to see if it can prevent stomach problems just as well as the standard treatment for heart patients who are taking blood thinners.

  Recruiting at 36 sites Phase 4 Asan Medical Center · Anyang and 44 other locations · NCT04416581

• Registry of patients treated with percutaneous coronary interventions at University of Fribourg

  This study tracks patients who receive stents for heart artery problems at the University of Fribourg to see how they do over time and improve treatment for everyone.

  Recruiting University of Freiburg · Fribourg · NCT04185285

• Comparing higher and lower doses of heparin for heart procedures

  This study is testing whether using a higher dose of heparin during heart procedures helps patients do better than using a lower dose.

  Recruiting Population Health Research Institute · Hamilton, Ontario · NCT04049591

• Registry for patients undergoing angioplasty in Korea

  This study is collecting information from patients who have had angioplasty to help understand how well the treatment works in real life.

  Recruiting Yonsei University · Seoul · NCT03908463

• Berberine's effect on blood platelets in heart patients after surgery

  This study is testing if adding berberine to the usual blood-thinning medications can help heart patients after surgery feel safer and reduce the risk of blood clots.

  Recruiting Phase 4 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT03378934

• Registry of patients with coronary artery issues and platelet test results

  This study collects information from patients with coronary artery disease to see how well their blood-thinning medications work and to find the best treatment options for them.

  Recruiting Action, France · Paris · NCT02762162

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Metasurface Optical Guidewire to Treat Coronary Artery Calcification

  A new optical guidewire technology aims to improve safety and effectiveness of coronary interventions in people with calcified arteries.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11468164

• Expansion of PCI use in different communities and who benefits

  Aims to understand how the growth of percutaneous coronary intervention (PCI) in outpatient and inpatient settings affects disadvantaged communities differently from non-disadvantaged ones.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11380038

• Catheter that helps treat complex heart artery problems more safely

  A new catheter device is being developed to help doctors deliver stents in very hard-to-treat heart artery cases, potentially making complex procedures safer and more effective.

  NIH research Vantis Vascular INC · Kalamazoo, United States · NIH-11316492

• Catheter that helps deliver stents in tough heart arteries

  A new guide-extension catheter system is being developed to safely reach and treat complex blockages in the heart’s blood vessels, especially where calcified and tortuous arteries make stent delivery hard.

  NIH research Vantis Vascular INC · Kalamazoo, United States · NIH-11261185

• How expanding artery-opening (PCI) procedures affects disadvantaged versus other communities

  This project looks at whether expanding artery-opening procedures (PCI) in hospitals and outpatient centers has helped or left behind people from disadvantaged communities with heart disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11135312

• A new catheter designed to improve complex heart procedures

  This study is testing a new type of catheter designed to help doctors place stents more easily and safely in patients with severe heart artery blockages, especially when the arteries are tricky to navigate.

  NIH research Crossliner INC · Kalamazoo, United States · NIH-11011323

• Using electronic health records to identify complications after heart procedures

  This study is working on a smart way to spot problems that can happen after a common heart procedure called PCI, using computer programs to look at health records, so that doctors can better keep you safe and provide the best care possible.

  NIH research Yale University · New Haven, United States · NIH-11001500

• Personalized blood-thinning treatment after heart procedures

  This study is looking at how to customize blood-thinning medications for people who have had heart procedures, by checking a specific gene that influences how well these medications work, so that each patient can get the best treatment to lower their risk of heart problems.

  NIH research University of Florida · Gainesville, United States · NIH-10875366

• New optical guidewires for treating blocked coronary arteries

  This study is testing new, flexible guidewires that use special light technology to help doctors treat blocked arteries in patients with hard, calcified arteries, making heart procedures safer and more effective.

  NIH research University of California-Irvine · Irvine, United States · NIH-10865571

Related topics

Quick answers

How many Percutaneous Coronary Intervention clinical trials are recruiting right now?

41, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in China (11 trials), South Korea (7 trials), Switzerland (3 trials), Denmark (3 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 7, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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